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1
Rhinovirus infection in young children is associated with elevated airway TSLP levels.幼儿鼻病毒感染与气道TSLP水平升高有关。
Eur Respir J. 2014 Oct;44(4):1075-8. doi: 10.1183/09031936.00049214. Epub 2014 Jun 25.
2
Rhinovirus infection interferes with induction of tolerance to aeroantigens through OX40 ligand, thymic stromal lymphopoietin, and IL-33.鼻病毒感染通过OX40配体、胸腺基质淋巴细胞生成素和白细胞介素-33干扰对气传抗原的耐受性诱导。
J Allergy Clin Immunol. 2016 Jan;137(1):278-288.e6. doi: 10.1016/j.jaci.2015.05.007. Epub 2015 Jun 19.
3
The Innate Cytokines IL-25, IL-33, and TSLP Cooperate in the Induction of Type 2 Innate Lymphoid Cell Expansion and Mucous Metaplasia in Rhinovirus-Infected Immature Mice.先天性细胞因子白细胞介素-25、白细胞介素-33和胸腺基质淋巴细胞生成素协同诱导鼻病毒感染的未成熟小鼠2型先天性淋巴细胞扩增和黏液化生。
J Immunol. 2017 Aug 15;199(4):1308-1318. doi: 10.4049/jimmunol.1700216. Epub 2017 Jul 12.
4
TLR3- and Th2 cytokine-dependent production of thymic stromal lymphopoietin in human airway epithelial cells.人呼吸道上皮细胞中Toll样受体3及Th2细胞因子依赖性胸腺基质淋巴细胞生成素的产生
J Immunol. 2007 Jul 15;179(2):1080-7. doi: 10.4049/jimmunol.179.2.1080.
5
Thymic stromal lymphopoietin and apocynin alter the expression of airway remodeling factors in human rhinovirus-infected cells.胸腺基质淋巴细胞生成素和白杨素改变人鼻病毒感染细胞中气道重塑因子的表达。
Immunobiology. 2017 Aug;222(8-9):892-899. doi: 10.1016/j.imbio.2017.05.010. Epub 2017 May 16.
6
Viral stimuli trigger exaggerated thymic stromal lymphopoietin expression by chronic obstructive pulmonary disease epithelium: role of endosomal TLR3 and cytosolic RIG-I-like helicases.病毒刺激物通过慢性阻塞性肺疾病上皮细胞引发过度的胸腺基质淋巴细胞生成素表达：内体 TLR3 和胞质 RIG-I 样螺旋酶的作用。
J Innate Immun. 2012;4(1):86-99. doi: 10.1159/000329131. Epub 2011 Jun 20.
7
Inhaled dsRNA and rhinovirus evoke neutrophilic exacerbation and lung expression of thymic stromal lymphopoietin in allergic mice with established experimental asthma.吸入双链 RNA 和鼻病毒会在已建立实验性哮喘的过敏性小鼠中引发中性粒细胞加重和肺部胸腺基质淋巴细胞生成素的表达。
Allergy. 2014 Mar;69(3):348-58. doi: 10.1111/all.12329. Epub 2013 Nov 28.
8
Emotional style, nasal cytokines, and illness expression after experimental rhinovirus exposure.实验性鼻病毒暴露后的情绪风格、鼻腔细胞因子与疾病表现
Brain Behav Immun. 2006 Mar;20(2):175-81. doi: 10.1016/j.bbi.2005.05.005. Epub 2005 Jul 14.
9
Inhibition of Virus-Induced Cytokine Production from Airway Epithelial Cells by the Late Addition of Budesonide.布地奈德对气道上皮细胞病毒诱导细胞因子产生的抑制作用：晚期添加。
Medicina (Kaunas). 2020 Feb 27;56(3):98. doi: 10.3390/medicina56030098.
10
Thymic stromal lymphopoietin, IL-33, and periostin in hospitalized infants with viral bronchiolitis.住院病毒性细支气管炎婴儿中的胸腺基质淋巴细胞生成素、白细胞介素-33和骨膜蛋白
Medicine (Baltimore). 2017 May;96(18):e6787. doi: 10.1097/MD.0000000000006787.

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1
Clinical Significance of Rhinoviruses and Progress Toward Vaccination.鼻病毒的临床意义及疫苗接种进展
Allergy Asthma Immunol Res. 2025 Jul;17(4):414-432. doi: 10.4168/aair.2025.17.4.414.
2
Common Pathogeneses Underlying Asthma and Chronic Obstructive Pulmonary Disease -Insights from Genetic Studies.哮喘和慢性阻塞性肺疾病的共同发病机制——来自遗传学研究的见解
Int J Chron Obstruct Pulmon Dis. 2024 Mar 4;19:633-642. doi: 10.2147/COPD.S441992. eCollection 2024.
3
Thymic stromal lymphopoietin participates in the host response to intra-amniotic inflammation leading to preterm labor and birth.胸腺基质淋巴细胞生成素参与宿主对羊膜内炎症的反应，导致早产和分娩。
Hum Immunol. 2023 Sep;84(9):450-463. doi: 10.1016/j.humimm.2023.06.005. Epub 2023 Jul 6.
4
Interferons as negative regulators of ILC2s in allergic lung inflammation and respiratory viral infections.干扰素作为过敏性肺部炎症和呼吸道病毒感染中 ILC2s 的负调控因子。
J Mol Med (Berl). 2023 Aug;101(8):947-959. doi: 10.1007/s00109-023-02345-0. Epub 2023 Jul 6.
5
SARS-CoV-2-Induced TSLP Is Associated with Duration of Hospital Stay in COVID-19 Patients.SARS-CoV-2 诱导的 TSLP 与 COVID-19 患者的住院时间有关。
Viruses. 2023 Feb 17;15(2):556. doi: 10.3390/v15020556.
6
Type 2 cytokine genes as allergic asthma risk factors after viral bronchiolitis in early childhood.2 型细胞因子基因作为婴幼儿期病毒性毛细支气管炎后过敏性哮喘的危险因素。
Front Immunol. 2023 Jan 6;13:1054119. doi: 10.3389/fimmu.2022.1054119. eCollection 2022.
7
TSLP bronchoalveolar lavage levels at baseline are linked to clinical disease severity and reduced lung function in children with asthma.哮喘患儿基线时的TSLP支气管肺泡灌洗水平与临床疾病严重程度及肺功能降低相关。
Front Pediatr. 2022 Sep 29;10:971073. doi: 10.3389/fped.2022.971073. eCollection 2022.
8
GSDM gene polymorphisms regulate the IgE level in asthmatic patients.GSDM 基因多态性调节哮喘患者的 IgE 水平。
PLoS One. 2022 Oct 6;17(10):e0274951. doi: 10.1371/journal.pone.0274951. eCollection 2022.
9
T-helper 2 mechanisms involved in human rhinovirus infections and asthma.辅助性 T 细胞 2 机制在人类鼻病毒感染和哮喘中的作用。
Ann Allergy Asthma Immunol. 2022 Dec;129(6):681-691. doi: 10.1016/j.anai.2022.08.015. Epub 2022 Aug 21.
10
TSLP, IL-33, and IL-25: Not just for allergy and helminth infection.TSLP、IL-33 和 IL-25：不仅与过敏和寄生虫感染有关。
J Allergy Clin Immunol. 2022 Dec;150(6):1302-1313. doi: 10.1016/j.jaci.2022.07.003. Epub 2022 Jul 19.

本文引用的文献

1
Airway inflammation and illness severity in response to experimental rhinovirus infection in asthma.哮喘患者对实验性鼻病毒感染的气道炎症与疾病严重程度
Chest. 2014 Jun;145(6):1219-1229. doi: 10.1378/chest.13-1567.
2
Inhaled dsRNA and rhinovirus evoke neutrophilic exacerbation and lung expression of thymic stromal lymphopoietin in allergic mice with established experimental asthma.吸入双链 RNA 和鼻病毒会在已建立实验性哮喘的过敏性小鼠中引发中性粒细胞加重和肺部胸腺基质淋巴细胞生成素的表达。
Allergy. 2014 Mar;69(3):348-58. doi: 10.1111/all.12329. Epub 2013 Nov 28.
3
Correlation between nitrites in induced sputum and asthma symptoms in asthmatic schoolchildren.哮喘学龄儿童诱导痰中亚硝酸盐与哮喘症状的相关性。
Pediatr Pulmonol. 2014 Mar;49(3):214-20. doi: 10.1002/ppul.22843. Epub 2013 Jul 10.
4
Thymic stromal lymphopoietin receptor blockade reduces allergic inflammation in a cynomolgus monkey model of asthma.胸腺基质淋巴细胞生成素受体阻断可减少食蟹猴哮喘模型中的过敏炎症。
J Allergy Clin Immunol. 2013 Aug;132(2):455-62. doi: 10.1016/j.jaci.2013.05.011. Epub 2013 Jun 26.
5
Thymic stromal lymphopoietin amplifies the differentiation of alternatively activated macrophages.胸腺基质淋巴细胞生成素扩增了选择性激活的巨噬细胞的分化。
J Immunol. 2013 Feb 1;190(3):904-12. doi: 10.4049/jimmunol.1201808. Epub 2012 Dec 28.
6
Hop water extract inhibits double-stranded RNA-induced thymic stromal lymphopoietin release from human nasal epithelial cells.Hop 水提物抑制人鼻上皮细胞中双链 RNA 诱导的胸腺基质淋巴细胞生成素释放。
Am J Rhinol Allergy. 2012 Nov-Dec;26(6):433-8. doi: 10.2500/ajra.2012.26.3814.
7
Assessment of airflow limitation, airway inflammation, and symptoms during virus-induced wheezing episodes in 4- to 6-year-old children.评估 4 至 6 岁儿童病毒诱发喘息发作期间的气流受限、气道炎症和症状。
J Allergy Clin Immunol. 2013 Jan;131(1):87-93.e1-5. doi: 10.1016/j.jaci.2012.10.033. Epub 2012 Nov 27.
8
Neonatal rhinovirus infection induces mucous metaplasia and airways hyperresponsiveness.新生儿鼻病毒感染可诱导黏液化生和气道高反应性。
J Immunol. 2012 Mar 15;188(6):2894-904. doi: 10.4049/jimmunol.1101391. Epub 2012 Feb 13.
9
Double-stranded RNA induces disproportionate expression of thymic stromal lymphopoietin versus interferon-beta in bronchial epithelial cells from donors with asthma.双链 RNA 诱导哮喘供体支气管上皮细胞中胸腺基质淋巴细胞生成素与干扰素-β的不成比例表达。
Thorax. 2010 Jul;65(7):626-32. doi: 10.1136/thx.2009.125930.
10
Sensing the outside world: TSLP regulates barrier immunity.感知外界：TSLP 调节屏障免疫。
Nat Immunol. 2010 Apr;11(4):289-93. doi: 10.1038/ni.1852.

Rhinovirus infection in young children is associated with elevated airway TSLP levels.

作者信息

Perez Geovanny F, Pancham Krishna, Huseni Shehlanoor, Preciado Diego, Freishtat Robert J, Colberg-Poley Anamaris M, Hoffman Eric P, Rose Mary C, Nino Gustavo

机构信息

Division of Pulmonary and Sleep Medicine, Children's National Medical Center, Washington, DC, USA.

Dept of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC, USA Dept of Integrative Systems Biology, George Washington University, Washington, DC, USA Center for Genetic Research Medicine, Children's National Medical Center, Washington, DC, USA Division of Pediatric Otorhinolaryngology, Depts of Surgery and Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.

出版信息

Eur Respir J. 2014 Oct;44(4):1075-8. doi: 10.1183/09031936.00049214. Epub 2014 Jun 25.

DOI:10.1183/09031936.00049214
PMID:24969655
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4183718/
Abstract
摘要