Han Ye, Xue Xiao-Feng, Shen Hu-Gang, Guo Xiao-Bo, Wang Xu, Yuan Bin, Guo Xing-Po, Kuang Yu-Ting, Zhi Qiao-Ming, Zhao Hong
Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China E-mail :
Asian Pac J Cancer Prev. 2014;15(11):4583-7. doi: 10.7314/apjcp.2014.15.11.4583.
Beclin-1 has recently been observed as an essential marker of autophagy in several cancers. However, the prognostic role of Beclin-1 in colorectal neoplasia remains controversial. Our study aimed to evaluate the potential association between Beclin-1 expression and the outcome of colorectal cancer patients.
All related studies were systematically searched in Pubmed, Embase, Springer and Chinese National Knowledge Infrastructure databases (CNKI), and then a meta-analysis was performed to determine the association of Beclin-1 expression with clinical outcomes. Finally, a total of 6 articles were included in our analysis.
Our data showed that high Beclin-1 expression in patients with CRC was associated with poor prognosis in terms of tumor distant metastasis (OR=2.090, 95%CI=1.061-4.119, p=0.033) and overall survival (RR=1.422, 95%CI=1.032-1.959, p=0.031). However, we did not found any correlation between Beclin-1 over-expression and tumor differentiation (OR=1.711, 95%CI=0.920-3.183, p=0.090). In addition, there was no evidence of publication bias as suggested by Egger's tests for tumor distant metastasis (p=1.000), differentiation (p=1.000) and OS (p=0.308).
Our present meta-analysis indicated that elevated Beclin-1 expression iss associated with tumor metastasis and a poor prognosis in patients with CRC. Beclin-1 might serve as an efficient prognostic indicator in CRC, and could be a new molecular target in CRC therapy.
最近在几种癌症中观察到Beclin-1是自噬的重要标志物。然而，Beclin-1在结直肠肿瘤形成中的预后作用仍存在争议。我们的研究旨在评估Beclin-1表达与结直肠癌患者预后之间的潜在关联。
在PubMed、Embase、Springer和中国知网数据库（CNKI）中系统检索所有相关研究，然后进行荟萃分析以确定Beclin-1表达与临床结局的关联。最后，我们的分析共纳入6篇文章。
我们的数据显示，结直肠癌患者中Beclin-1高表达与肿瘤远处转移（OR=2.090，95%CI=1.061-4.119，p=0.033）和总生存期（RR=1.422，95%CI=1.032-1.959，p=0.031）方面的预后不良相关。然而，我们未发现Beclin-1过表达与肿瘤分化之间存在任何相关性（OR=1.711，95%CI=0.920-3.183，p=0.090）。此外，Egger检验显示肿瘤远处转移（p=1.000）、分化（p=1.000）和总生存期（p=0.308）均无发表偏倚的证据。
我们目前的荟萃分析表明，Beclin-1表达升高与结直肠癌患者的肿瘤转移和预后不良相关。Beclin-1可能作为结直肠癌的有效预后指标，并且可能成为结直肠癌治疗的新分子靶点。
