ABO血型与癌症风险：一项系统评价和荟萃分析。
ABO blood groups and risk of cancer: a systematic review and meta-analysis.
作者信息
Zhang Bai-Lin, He Na, Huang Yu-Bei, Song Feng-Ju, Chen Ke-Xin
机构信息
Department of Radiotherapy, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center of Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, China E-mail : chenkexin1963@yahoo. com,
出版信息
Asian Pac J Cancer Prev. 2014;15(11):4643-50. doi: 10.7314/apjcp.2014.15.11.4643.
BACKGROUND
For decades, studies have been performed to evaluate the association between ABO blood groups and risk of cancer. However, whether ABO blood groups are associated with overall cancer risk remains unclear. We therefore conducted a meta-analysis of observational studies to assess this association.
MATERIALS AND METHODS
A search of Pubmed, Embase, ScienceDirect, Wiley, and Web of Knowledge databases (to May 2013) was supplemented by manual searches of bibliographies of key retrieved articles and relevant reviews. We included case-control studies and cohort studies with more than 100 cancer cases.
RESULTS
The search yielded 89 eligible studies that reported 100,554 cases at 30 cancer sites. For overall cancer risk, the pooled OR was 1.12 (95%CI: 1.09-1.16) for A vs. non- A groups, and 0.84 (95%CI: 0.80-0.88) for O vs. non-O groups. For individual cancer sites, blood group A was found to confer increased risk of gastric cancer (OR=1.18; 95%CI: 1.13-1.24), pancreatic cancer (OR=1.23; 95%CI: 1.15-1.32), breast cancer (OR=1.12; 95%CI: 1.01-1.24), ovarian cancer (OR=1.16; 95%CI: 1.04-1.27), and nasopharyngeal cancer (OR=1.17; 95%CI: 1.00-1.33). Blood group O was found to be linked to decreased risk of gastric cancer (OR=0.84; 95%CI: 0.80-0.88), pancreatic cancer (OR=0.75; 95%CI: 0.70-0.80), breast cancer (OR=0.90; 95%CI: 0.85-0.95), colorectal cancer (OR=0.89; 95%CI: 0.81-0.96), ovarian cancer (OR=0.76; 95%CI: 0.53-1.00), esophagus cancer (OR=0.94; 95%CI: 0.89-1.00), and nasopharyngeal cancer (OR=0.81; 95%CI: 0.70-0.91).
CONCLUSIONS
Blood group A is associated with increased risk of cancer, and blood group O is associated with decreased risk of cancer.
背景
几十年来，人们一直进行研究以评估ABO血型与癌症风险之间的关联。然而，ABO血型是否与总体癌症风险相关仍不明确。因此，我们进行了一项观察性研究的荟萃分析来评估这种关联。
材料与方法
检索了Pubmed、Embase、ScienceDirect、Wiley和Web of Knowledge数据库（截至2013年5月），并通过手工检索关键检索文章的参考文献和相关综述进行补充。我们纳入了病例对照研究和癌症病例超过100例的队列研究。
结果
检索得到89项符合条件的研究，这些研究报告了30个癌症部位的100,554例病例。对于总体癌症风险，A组与非A组相比，合并OR为1.12（95%CI：1.09 - 1.16），O组与非O组相比，合并OR为0.84（95%CI：0.80 - 0.88）。对于个别癌症部位，发现A型血会增加患胃癌（OR = 1.18；95%CI：1.13 - 1.24）、胰腺癌（OR = 1.23；95%CI：1.15 - 1.32）、乳腺癌（OR = 1.12；95%CI：1.01 - 1.24）、卵巢癌（OR = 1.16；95%CI：1.04 - 1.27）和鼻咽癌（OR = 1.17；95%CI：1.00 - 1.33）的风险。发现O型血与降低患胃癌（OR = 0.84；95%CI：0.80 - 0.88）、胰腺癌（OR = 0.75；95%CI：0.70 - 0.80）、乳腺癌（OR = 0.90；95%CI：0.85 - 0.95）、结直肠癌（OR = 0.89；95%CI：0.81 - 0.96）、卵巢癌（OR = 0.76；95%CI：0.53 - 1.00）、食管癌（OR = 0.94；95%CI：0.89 - 1.00）和鼻咽癌（OR = 0.81；95%CI：0.70 - 0.91）的风险相关。
结论
A型血与癌症风险增加相关，O型血与癌症风险降低相关。
Zotero 插件