Çelik Süleyman Utku, Gülap Yasin, Bahadır Demir Mehmet, Kaymak Şahin, Şenocak Rahman
Clinic of General Surgery, Gülhane Training and Research Hospital, Ankara, Türkiye.
Turk J Surg. 2024 Sep 30;40(3):240-246. doi: 10.47717/turkjsurg.2024.6434. eCollection 2024 Sep.
This study aimed to examine the association between blood groups and clinicopathological factors that could affect the prognosis of patients with gastric cancer.
In this retrospective single-center study, patients with gastric adenocarcinoma were obtained from a prospectively maintained database. The association between blood groups and clinicopathologic characteristics including sex, age, tumor location, tumor size, tumor stage, metastatic lymph node ratio (MLR), lymphovascular invasion, and perineural invasion were analyzed.
The study included 91 female and 221 male patients. The blood group distribution was A>O>B>AB both in the patients and healthy donors. Non-O blood types were more common in cancer patients than in healthy donors (p= 0.038). However, there was no significant association between sex, age, tumor location, tumor stage, lymph node status, lymphovascular invasion, and perineural involvement and blood groups. ≥7 lymph node involvement and MLR of >0.6 were significantly more common in patients with blood group A than in those with non-A blood groups (p= 0.034 and p= 0.018; respectively).
The findings of this study suggest that blood group A patients are associated with higher MLR and N3 involvement, so it is possible that these patients with gastric cancer have a poorer prognosis.
本研究旨在探讨血型与可能影响胃癌患者预后的临床病理因素之间的关联。
在这项回顾性单中心研究中，胃腺癌患者来自一个前瞻性维护的数据库。分析了血型与临床病理特征之间的关联，这些特征包括性别、年龄、肿瘤位置、肿瘤大小、肿瘤分期、转移淋巴结比例（MLR）、淋巴管侵犯和神经周围侵犯。
该研究纳入了91名女性和221名男性患者。患者和健康供者的血型分布均为A>O>B>AB。癌症患者中非O血型比健康供者更常见（p = 0.038）。然而，性别、年龄、肿瘤位置、肿瘤分期、淋巴结状态、淋巴管侵犯和神经周围受累与血型之间无显著关联。血型为A的患者中≥7个淋巴结受累和MLR>0.6的情况明显比非A血型患者更常见（分别为p = 0.034和p = 0.018）。
本研究结果表明，血型为A的患者与较高的MLR和N3受累相关，因此这些胃癌患者的预后可能较差。
