Department of Clinical Laboratory, Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, Zhejiang, China.
Department of Pathology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
BMJ Open. 2024 Oct 15;14(10):e088016. doi: 10.1136/bmjopen-2024-088016.
This research aims to explore the correlation between ABO blood groups and neoplasms in the head and neck region, specifically investigating the susceptibility of different blood groups to tumours.
Systematic review and meta-analysis.
CNKI, WANFANG DATA, PubMed, Web of Science and Embase databases were systematically searched from inception to January 2024.
All studies of ABO blood type and head and neck tumours will be included in this study.
A systematic literature review was performed using digital platforms on CNKI, WANFANG DATA, PubMed, Web of Science and Embase databases, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines for meta-analysis. Two authors independently extracted the data and assessed the quality of included studies. The Newcastle-Ottawa Scale was used to assess the quality of the included studies. Comparisons were made between blood types A, B, AB and their combined group versus O, along with subgroup analyses. Systematic analysis was performed by using Review Manager V.5.4 and Stata V.18 statistical software.
30 articles were included, involving 737 506 subjects, among which 21 382 were patients with head and neck tumours. The overall analysis indicated a significant association between type AB blood (OR 0.762, 95% CI 0.637 to 0.910) and a reduced risk of head and neck tumours. In the Caucasoid race, type A blood is significantly linked to an elevated likelihood of head and neck tumours (OR 1.353, 95% CI 1.076 to 1.702), while in the Mongoloid race, type AB blood is significantly linked to a reduced likelihood of developing tumours in the head and neck area (OR= 0.732, 95% CI 0.588 to 0.910). No significant associations were found in the subgroup analysis by gender. Regarding different types of cancer, type A blood is significantly associated with an increased risk of salivary gland tumours (OR 1.338, 95% CI 1.075 to 1.665), and type AB blood is significantly linked to a lower likelihood of nasopharyngeal carcinoma (OR 0.590, 95% CI 0.429 to 0.812).
A correlation exists between ABO blood groups and tumours in the head and neck region. However, the link between blood type and head and neck tumours requires further confirmation through more prospective studies.
CRD42024510176.
本研究旨在探讨 ABO 血型与头颈部肿瘤之间的相关性，具体探讨不同血型对肿瘤的易感性。
系统评价和荟萃分析。
CNKI、万方数据、PubMed、Web of Science 和 Embase 数据库自成立以来至 2024 年 1 月进行了系统检索。
所有关于 ABO 血型与头颈部肿瘤的研究都将纳入本研究。
使用数字平台对 CNKI、万方数据、PubMed、Web of Science 和 Embase 数据库进行系统文献综述，按照系统评价和荟萃分析的首选报告项目进行荟萃分析。两名作者独立提取数据并评估纳入研究的质量。采用纽卡斯尔-渥太华量表评估纳入研究的质量。比较了 A、B、AB 血型及其组合与 O 型血，同时进行了亚组分析。使用 Review Manager V.5.4 和 Stata V.18 统计软件进行系统分析。
纳入 30 篇文章，涉及 737506 名受试者，其中 21382 名为头颈部肿瘤患者。总体分析表明，AB 型血（OR 0.762，95%CI 0.637 至 0.910）与头颈部肿瘤风险降低之间存在显著关联。在白种人中，A型血与头颈部肿瘤的发生风险显著升高（OR 1.353，95%CI 1.076 至 1.702），而在蒙古人种中，AB 型血与头颈部肿瘤的发生风险显著降低（OR=0.732，95%CI 0.588 至 0.910）。亚组分析按性别未发现显著关联。关于不同类型的癌症，A型血与唾液腺癌的发生风险显著升高（OR 1.338，95%CI 1.075 至 1.665）相关，而 AB 型血与鼻咽癌的发生风险显著降低（OR 0.590，95%CI 0.429 至 0.812）相关。
ABO 血型与头颈部肿瘤之间存在相关性。然而，血型与头颈部肿瘤之间的联系需要通过更多的前瞻性研究进一步证实。
PROSPERO 注册号：CRD42024510176。
