Mo Cui-Ju, Peng Qi-Liu, He Yu, Wang Jian, Xie Li, Li Tai-Jie, Li Shan, Qin Xue
Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China E-mail :
Asian Pac J Cancer Prev. 2014;15(11):4697-703. doi: 10.7314/apjcp.2014.15.11.4697.
Interleukin-16 (IL-16) is a multifunctional cytokine which plays a key role in inflammatory and autoimmune diseases as well as in cancer. Genetic polymorphisms of IL-16 have been implicated in susceptibility to cancer. However, associations remain inconclusive. The present meta-analysis was therefore carried out to establish a more conclusive association of IL-16 polymorphisms with cancer risk.
Relevant studies were searched through the PubMed, Embase, Web of Science, Google Scholar and Wan fang electronic databases updated in October 2013. Odds ratios (OR) and 95% confidence intervals (95% CI) were used to assess the association between IL-16 polymorphisms and cancer risk.
Eight eligible studies (rs4778889 T/C: 8, rs11556218 T/G: 7, rs4072111 C/T: 6) that met our selection criteria were included. The meta-analysis indicated that rs11556218 T/G was associated with a significant increased risk of cancer (G vs. T, OR=1.321, 95% CI=1.142-1.528, P <0.001; TG vs. TT, OR=1.665, 95% CI=1.448-1.915, P<0.001; GG+TG vs. TT, OR=1.622, 95% CI=1.416-1.858, P<0.001),as well as nasopharyngeal carcinoma and colorectal cancer. Furthermore, in the subgroup of Chinese, significant associations were found between rs11556218 polymorphism and cancer risk. There was no statistically significant association between the other two variants (rs4778889, rs4072111) and risk of cancer.
This meta-analysis suggests that the IL-16 rs11556218 polymorphism is associated with increased cancer risk. Large well-designed studies involving various cancer types and different populations are now needed.
白细胞介素 -16（IL -16）是一种多功能细胞因子，在炎症性疾病、自身免疫性疾病以及癌症中发挥关键作用。IL -16的基因多态性与癌症易感性有关。然而，相关关联仍无定论。因此，开展本荟萃分析以确定IL -16基因多态性与癌症风险之间更具结论性的关联。
通过检索2013年10月更新的PubMed、Embase、科学网、谷歌学术和万方电子数据库获取相关研究。采用比值比（OR）和95%置信区间（95%CI）评估IL -16基因多态性与癌症风险之间的关联。
纳入了8项符合我们选择标准的合格研究（rs4778889 T/C：8项，rs11556218 T/G：7项，rs4072111 C/T：6项）。荟萃分析表明，rs11556218 T/G与癌症风险显著增加相关（G vs. T，OR = 1.321, 95%CI = 1.142 - 1.528, P < 0.001；TG vs. TT，OR = 1.665, 95%CI = 1.448 - 1.915, P < 0.001；GG + TG vs. TT，OR = 1.622, 95%CI = 1.416 - 1.858, P < 0.001），以及与鼻咽癌和结直肠癌相关。此外，在中国人群亚组中，发现rs11556218多态性与癌症风险之间存在显著关联。其他两个变体（rs4778889、rs4072111）与癌症风险之间无统计学显著关联。
本荟萃分析表明，IL -16 rs11556218多态性与癌症风险增加相关。现在需要开展涉及各种癌症类型和不同人群的大型精心设计的研究。
