Elgenidy Anas, Alomari Omar, Hesn Mohamed Marey, Khaled Anas, Nada Sarah A, Elsayed Mostafa, Mahmoud Ali, Al-Kurdi Mohammed Al-Mahdi, Afifi Ahmed M, Cholankeril George
Department of Neurology, Cairo University, Cairo 11652, Egypt.
Hamidiye International School of Medicine, University of Health Sciences, 34668 Istanbul, Turkey.
Cancers (Basel). 2024 Dec 21;16(24):4262. doi: 10.3390/cancers16244262.
: Many researchers believe that cardia (CGC) and non-cardia (NCGC) are two different types of tumors, having different features like incidence rate, risk factors, geographical location, and socioeconomic status. This study aims to investigate the causes of death (COD) survival rates among early gastric cancer patients with a focus on differences between CGC and NCGC. : This retrospective study employed SEER*stat software (version 8.3.92) to analyze the SEER 17 plus dataset (2000-2019). Standardized mortality ratios (SMR) were computed. Relative survival and conditional survival post-diagnosis were calculated using R software (version 4.1.0) among the different subgroups. : Within the follow-up period, 55.4% (5381) died, predominantly within the initial year post-diagnosis. Esophageal cancer was the leading non-gastric cancer cause in CGC, while miscellaneous tumors dominated in NCGC. The 1-year and 5-year relative survival for CGC patients were 76.4% and 48.9% respectively, while for NCGC were 80.4% and 63.9%. The 3-year conditional survival after 1 year and 5e years of survival for CGC were 68.7% and 88.8%, respectively, while for NCGC were 82.2% and 93.5%, respectively. This means that the longer a person has survived after diagnosis with cancer, the greater the likelihood that person will survive for another 3 years. : This study sheds light on the substantial impact of non-cancer COD in GC patients, underscoring the necessity of considering comorbidities in their comprehensive management and follow-up. : This study contributes valuable insights for clinical decision-making and informs future research directions regarding CGC and NCGC.
许多研究人员认为，贲门癌（CGC）和非贲门癌（NCGC）是两种不同类型的肿瘤，在发病率、风险因素、地理位置和社会经济地位等方面具有不同特征。本研究旨在调查早期胃癌患者的死亡原因（COD）生存率，重点关注CGC和NCGC之间的差异。：这项回顾性研究使用SEER*stat软件（8.3.92版）分析SEER 17加数据集（2000 - 2019年）。计算标准化死亡率（SMR）。使用R软件（4.1.0版）计算不同亚组诊断后的相对生存率和条件生存率。：在随访期内，55.4%（5381例）死亡，主要在诊断后的第一年。食管癌是CGC中主要的非胃癌死因，而在NCGC中其他肿瘤占主导。CGC患者的1年和5年相对生存率分别为76.4%和48.9%，而NCGC患者分别为80.4%和63.9%。CGC患者在生存1年和5年后的3年条件生存率分别为68.7%和88.8%，而NCGC患者分别为82.2%和93.5%。这意味着癌症诊断后存活时间越长的人，再存活3年的可能性就越大。：本研究揭示了非癌症COD对GC患者的重大影响，强调了在其综合管理和随访中考虑合并症的必要性。：本研究为临床决策提供了有价值的见解，并为关于CGC和NCGC的未来研究方向提供了信息。
