Department of Cardiology and LTTA Centre, University Hospital of Ferrara, Ferrara, Italy
GVM Care and Research, E.S: Health Science Foundation, Maria Cecilia Hospital, Cotignola, Italy.
Eur Heart J. 2014 Aug 21;35(32):2140-5. doi: 10.1093/eurheartj/ehu244. Epub 2014 Jun 26.
Pathological ventricle remodelling, which follows a cardiac insult, causes heart failure. Despite the existence of multiple pharmaceutical approaches, heart failure is one of the leading causes of death worldwide and there is an urgent need to explore new therapeutic avenues. The Notch pathway is an evolutionary conserved fundamental pathway that regulates cell fate during development as well as throughout postnatal life in self-renewing tissues. In the myocardium, Notch signalling is involved in the modulation of cardiomyocytes survival, cardiac stem cells differentiation, and angiogenesis which are factors known to determine the extent of pathological cardiac remodelling. Modulation of the Notch pathway could become a tool to limit ventricle remodelling and the associated inexorable deterioration of cardiac performance.
病理性心室重构是心脏损伤后的一种反应，会导致心力衰竭。尽管有多种药物治疗方法，但心力衰竭仍是全球主要死亡原因之一，因此迫切需要探索新的治疗途径。Notch 通路是一种进化上保守的基本通路，它在发育过程中以及在自我更新组织的出生后生命中调节细胞命运。在心肌中，Notch 信号参与调节心肌细胞存活、心脏干细胞分化和血管生成，这些因素被认为决定了病理性心脏重构的程度。Notch 通路的调节可能成为限制心室重构和相关心脏功能不可避免恶化的一种手段。
