Prokšelj Tatjana, Jerin Aleš, Muck-Seler Dorotea, Kogoj Aleš
Psychiatric Hospital Begunje, Psychiatric Intensive Care Unit, Begunje na Gorenjskem 55, 4275 Begunje na Gorenjskem, Slovenia.
Institute of Clinical Chemistry and Biochemistry, University Medical Center Ljubljana, Njegoševa 4, 1525 Ljubljana, Slovenia.
Neurosci Lett. 2014 Aug 22;578:71-4. doi: 10.1016/j.neulet.2014.06.034. Epub 2014 Jun 23.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder manifested by progressive decline in cognitive functions. A variety of behavioral disturbances appear very often in AD which might be associated with altered function of serotoninergic system. The aim of the study was to determine platelet serotonin (5-HT) concentrations in 49 patients with AD (NINCDS-ADRDA and DSM-IV-TR criteria) subdivided in three groups: (a) patients with aggressive behavior, (b) patients with involuntary emotional expression disorder (IEED) and (c) patients without aggression or IEED (controls). Platelet 5-HT concentrations were measured using ELISA. Platelet 5-HT concentrations were significantly lower in patients with AD and co-existing IEED compared to AD patients with aggressive behavior or control patients. No significant difference in platelet 5-HT concentrations was found between patients expressing aggressive behavior and controls. Our results suggest disruptions in serotoninergic system in AD patients with comorbid IEED but not with aggressive behavior and support the presumption that platelet 5-HT concentration is a suitable and easy measured peripheral indicator of some behavioral and psychological symptoms of AD.
阿尔茨海默病（AD）是一种进行性神经退行性疾病，表现为认知功能的逐渐衰退。各种行为障碍在AD中非常常见，这可能与血清素能系统功能改变有关。本研究的目的是测定49例符合NINCDS-ADRDA和DSM-IV-TR标准的AD患者的血小板血清素（5-HT）浓度，这些患者被分为三组：（a）有攻击行为的患者，（b）有不自主情感表达障碍（IEED）的患者，（c）无攻击行为或IEED的患者（对照组）。使用酶联免疫吸附测定法（ELISA）测量血小板5-HT浓度。与有攻击行为的AD患者或对照患者相比，伴有IEED的AD患者的血小板5-HT浓度显著降低。有攻击行为的患者与对照患者之间的血小板5-HT浓度未发现显著差异。我们的结果表明，合并IEED的AD患者的血清素能系统存在紊乱，但有攻击行为的患者不存在，这支持了血小板5-HT浓度是AD某些行为和心理症状的合适且易于测量的外周指标这一推测。
