Kumar A M, Sevush S, Kumar M, Ruiz J, Eisdorfer C
Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, FL 33101, USA.
Neuropsychobiology. 1995;32(1):9-12. doi: 10.1159/000119205.
The platelet has been suggested to be a peripheral model of the central serotonergic neuron. This investigation was carried out in order to test the hypothesis that levels of serotonin (5-HT) in the platelet will be decreased in Alzheimer's disease (AD) since neurochemical studies suggest that levels of 5-HT are decreased in the brain of AD patients. We investigated platelet and plasma 5-HT in a group of AD patients (n = 22) as well as in age-matched normal control subjects (n = 20). The results show that the platelet level of 5-HT was significantly reduced in AD (65.7 +/- 28.41 ng/10(8) platelets in AD vs. 112.9 +/- 35.11 ng/10(8) platelets in controls; p = 0.0001). There was no effect on the levels of its metabolite 5-hydroxyindoleacetic acid. These findings suggest that the peripheral serotonergic system in AD is adversely affected.
血小板已被认为是中枢5-羟色胺能神经元的外周模型。进行这项研究是为了检验以下假设：由于神经化学研究表明阿尔茨海默病（AD）患者大脑中的5-羟色胺（5-HT）水平降低，所以AD患者血小板中的5-HT水平也会降低。我们对一组AD患者（n = 22）以及年龄匹配的正常对照者（n = 20）的血小板和血浆5-HT进行了研究。结果显示，AD患者的血小板5-HT水平显著降低（AD患者为65.7±28.41 ng/10⁸个血小板，对照组为112.9±35.11 ng/10⁸个血小板；p = 0.0001）。其代谢产物5-羟吲哚乙酸的水平未受影响。这些发现表明AD患者的外周5-羟色胺能系统受到了不利影响。
