Department of Dermatology and Rheumatology, Affiliated Yan'an Hospital of Kunming Medical College, Kunming, Yunnan 650051, China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming, Yunnan 650201, China.
Int J Genomics. 2014;2014:870597. doi: 10.1155/2014/870597. Epub 2014 May 25.
Psoriasis is a chronic inflammatory and hyperproliferative skin disease affected by both genetic and environmental factors. The aim of the present study was to investigate polymorphisms in a candidate gene family of interleukin (IL) in unrelated Chinese patients with psoriasis and control subjects without psoriasis. In this case-control study, 200 unrelated Chinese psoriasis patients and 298 age- and sex-matched control subjects were enrolled. Genomic DNA was prepared from peripheral blood obtained from all psoriasis patients and control subjects. We genotyped seven single-nucleotide polymorphisms (SNPs) in candidate genes of six ILs: IL4, IL10, IL12B, IL13, IL15, and IL23R, which have been shown in the literature to be associated with psoriasis in other ethnic groups. Among the seven SNPs in the six IL genes studied, only the rs3212227 in the IL12B gene was found to be associated with psoriasis at genotypic level in the studied population. The C/C genotype in the IL12B gene is a protective factor of psoriasis (P = 0.0218; OR = 0.51; 95% CI: 0.27-0.96) in Chinese. Furthermore, the studied Chinese population has extremely low minor allele frequency for IL23R. Together, the data reveal unique genetic patterns in Chinese that may be in part responsible for the lower risk for psoriasis in this population.
银屑病是一种受遗传和环境因素影响的慢性炎症性和过度增生性皮肤病。本研究旨在研究白细胞介素（IL）候选基因家族中的多态性在无银屑病的中国无关银屑病患者和对照者中的作用。在这项病例对照研究中，纳入了 200 名无相关中国银屑病患者和 298 名年龄和性别匹配的对照者。从所有银屑病患者和对照者的外周血中提取基因组 DNA。我们对 6 个 IL 候选基因中的 7 个单核苷酸多态性（SNPs）进行了基因分型：IL4、IL10、IL12B、IL13、IL15 和 IL23R，这些基因在其他种族中与银屑病有关。在研究的六个 IL 基因中的七个 SNP 中，只有 IL12B 基因中的 rs3212227 在研究人群中与银屑病在基因型水平相关。IL12B 基因中的 C/C 基因型是银屑病的保护因素（P = 0.0218；OR = 0.51；95%CI：0.27-0.96）。此外，研究中的中国人群 IL23R 的次要等位基因频率极低。总之，这些数据揭示了中国人群独特的遗传模式，这可能部分解释了该人群银屑病风险较低的原因。
