Glasier A F, Irvine D S, Wickings E J, Hillier S G, Baird D T
Department of Obstetrics and Gynaecology, University of Edinburgh, UK.
Hum Reprod. 1989 Apr;4(3):252-6. doi: 10.1093/oxfordjournals.humrep.a136882.
An investigation of the effects on follicular development of clomiphene citrate and its two isomers En clomiphene and Zu clomiphene given separately was carried out on 19 normally cycling women being treated with donor insemination. All women received clomiphene citrate in the first cycle and, following a washout control cycle, were treated with either En clomiphene or Zu clomiphene alone. The number of follicles present, follicular phase oestrogen secretion and luteal phase pregnanediol excretion were not significantly different when Zu clomiphene cycles were compared with control cycles, but were significantly increased in En clomiphene and clomiphene citrate cycles. It is concluded that the En isomer, which has largely antioestrogenic properties, is the isomer active in inducing follicular development. The oestrogenic properties of Zu isomer did not appear to protect it from the possibly detrimental effects on sperm-cervical mucus interaction observed in both isomers and in the combined preparation.
对19名接受供体人工授精治疗的正常月经周期女性，分别给予枸橼酸氯米芬及其两种异构体恩氯米芬和珠氯米芬，研究它们对卵泡发育的影响。所有女性在第一个周期接受枸橼酸氯米芬治疗，经过一个洗脱对照周期后，单独接受恩氯米芬或珠氯米芬治疗。与对照周期相比，珠氯米芬周期时的卵泡数量、卵泡期雌激素分泌和黄体期孕二醇排泄无显著差异，但恩氯米芬和枸橼酸氯米芬周期时这些指标显著增加。得出的结论是，主要具有抗雌激素特性的恩异构体是诱导卵泡发育的活性异构体。珠异构体的雌激素特性似乎并未使其免受两种异构体及复方制剂中观察到的对精子 - 宫颈黏液相互作用可能产生的有害影响。
