Randall J M, Templeton A
Department of Obstetrics and Gynaecology, University of Aberdeen, Maternity Hospital, Scotland.
Fertil Steril. 1991 Sep;56(3):465-8. doi: 10.1016/s0015-0282(16)54541-5.
Assessment of the effects of clomiphene citrate (CC) on cervical mucus score and in vitro sperm mucus interaction.
Prospective study of cervical mucus score and in vitro sperm mucus interaction in a spontaneous cycle followed by a CC cycle to compare paired data.
Tertiary institutional infertility clinic.
PATIENTS, PARTICIPANTS: Twenty-two couples with primary unexplained infertility were studied in both cycles.
Clomiphene citrate (150 mg) on days 5 to 9 in CC cycles.
Cervical mucus score and sperm-mucus penetration test score.
Mean cervical mucus score in spontaneous cycles was 9.3 (95% confidence interval [CI] 8.4 to 10.2) and in CC cycles 5.6 (95% CI 4.6 to 6.6), P less than 0.0001. Sperm-mucus penetration test score in spontaneous cycles was 11.4 (95% CI 7.6 to 15.2) and in CC cycles 3.9 (95% CI 1.17 to 6.63), P less than 0.01.
Clomiphene citrate has an adverse effect on both cervical mucus score and sperm-mucus penetration.
评估枸橼酸氯米芬（CC）对宫颈黏液评分及体外精子与黏液相互作用的影响。
对自发周期及随后的CC周期中的宫颈黏液评分和体外精子与黏液相互作用进行前瞻性研究，以比较配对数据。
三级机构不孕症诊所。
患者、参与者：对22对原发性不明原因不孕症夫妇在两个周期中进行研究。
在CC周期的第5至9天给予枸橼酸氯米芬（150毫克）。
宫颈黏液评分和精子-黏液穿透试验评分。
自发周期的平均宫颈黏液评分为9.3（95%置信区间[CI]8.4至10.2），CC周期为5.6（95%CI4.6至6.6），P<0.0001。自发周期的精子-黏液穿透试验评分为11.4（95%CI7.6至15.2），CC周期为3.9（95%CI1.17至6.63），P<0.01。
枸橼酸氯米芬对宫颈黏液评分和精子-黏液穿透均有不利影响。
