Cui Hai-Lei, Tanaka Fujie
Chemistry and Chemical Bioengineering Unit, Okinawa Institute of Science and Technology Graduate University, 1919-1 Tancha, Onna, Okinawa 904-0495, Japan.
Org Biomol Chem. 2014 Aug 21;12(31):5822-6. doi: 10.1039/c4ob01019a.
One-pot syntheses of polysubstituted 3-acylpyrroles from readily available unsaturated ketones and N-substituted propargylated amines have been developed. An aza-Michael/alkyne carbocyclization cascade, by cooperative catalysis using pyrrolidine and a copper salt, followed by oxidation in situ gave 3-acylpyrroles, which were also transformed further to functionalized, highly substituted 3-acylpyrroles.
