Badenoch P R, Coster D J
Department of Ophthalmology, Flinders Medical Centre, Bedford Park, South Australia.
J Ocul Pharmacol. 1989 Spring;5(1):19-25. doi: 10.1089/jop.1989.5.19.
Pseudomonas aeruginosa often persists in ocular infections despite intensive antimicrobial therapy. In this study, gentamicin-resistant small colony variants (SCV) were selected in vitro from three gentamicin-susceptible Pseudomonas isolates by incubation with antibiotic. In the rat cornea, SCV were selected from two of these strains by administration of gentamicin either topically or intravenously. The selection of resistant variants may be a contributing factor in the persistence and reactivation frequently associated with ocular Pseudomonas infections.
尽管进行了强化抗菌治疗，铜绿假单胞菌仍常常在眼部感染中持续存在。在本研究中，通过与抗生素孵育，从三株对庆大霉素敏感的铜绿假单胞菌分离株中体外筛选出庆大霉素耐药小菌落变体（SCV）。在大鼠角膜中，通过局部或静脉给予庆大霉素，从其中两株菌株中筛选出SCV。耐药变体的选择可能是眼部铜绿假单胞菌感染经常出现的持续性和再激活的一个促成因素。
