Zamboni P, Tisato V, Menegatti E, Mascoli F, Gianesini S, Salvi F, Secchiero P
Vascular Disease Center, University of Ferrara, Italy Department of Morphology, Surgery, and Experimental Medicine, University of Ferrara, Italy
Department of Morphology, Surgery, and Experimental Medicine, University of Ferrara, Italy.
Phlebology. 2015 Oct;30(9):644-7. doi: 10.1177/0268355514541980. Epub 2014 Jun 27.
To study the ultrastructure of intraluminal defects found in the internal jugular vein by using a scanning electron microscopy.
Using a scanning electron microscopy, intraluminal septa and/or defective valves blocking the flow in the distal internal jugular vein of seven patients were studied together with the adjacent wall and compared with control specimen.
The internal jugular veins' wall showed a significant derangement of the endothelial layer as compared to controls. Surprisingly, no endothelial cells were found in the defective cusps, and the surface of the structure is covered by a fibro-reticular lamina.
Although the lack of endothelial cells in the internal jugular vein intraluminal obstacles is a further abnormality found in course of chronic cerebrospinal venous insufficiency, our investigation cannot clarify whether this finding is primary or caused by progressive loss of endothelium in relation to altered haemodynamic forces and/or to a past post-thrombotic/inflammatory remodelling.
运用扫描电子显微镜研究颈内静脉腔内缺陷的超微结构。
运用扫描电子显微镜，对7例患者颈内静脉远端存在阻塞血流的腔内隔膜和/或缺损瓣膜进行研究，并与相邻管壁一同与对照标本进行比较。
与对照组相比，颈内静脉壁的内皮细胞层出现明显紊乱。令人惊讶的是，在缺损的瓣尖未发现内皮细胞，且该结构表面覆盖有纤维网状薄片。
尽管颈内静脉腔内障碍物中缺乏内皮细胞是慢性脑脊髓静脉功能不全过程中发现的又一异常情况，但我们的研究无法阐明这一发现是原发性的，还是与血流动力学改变和/或既往血栓形成后/炎症重塑相关的内皮细胞渐进性丧失所致。
