Vida Stephen, Richardson Lesley, Cardis Elisabeth, Krewski Daniel, McBride Mary, Parent Marie-Elise, Abrahamowicz Michal, Leffondré Karen, Siemiatycki Jack
Centre de Recherche, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada.
Environ Health. 2014 Jun 27;13:55. doi: 10.1186/1476-069X-13-55.
There is conflicting evidence regarding the associations between cigarette smoking and glioma or meningioma. Our purpose is to provide further evidence on these possible associations.
We conducted a set of case-control studies in three Canadian cities, Montreal, Ottawa and Vancouver. The study included 166 subjects with glioma, 93 subjects with meningioma, and 648 population-based controls. A lifetime history of cigarette smoking was collected and various smoking indices were computed. Multivariable logistic regression was used to estimate odds ratios (ORs) between smoking and each of the two types of brain tumours.
Adjusted ORs between smoking and each type of brain tumour were not significantly elevated for all smokers combined or for smokers with over 15 pack-years ((packs / day) x years) accumulated. We tested for interactions between smoking and several sociodemographic variables; the interaction between smoking and education on glioma risk was significant, with smoking showing an elevated OR among subjects with lower education and an OR below unity among subjects with higher education.
Except for an unexplained and possibly artefactual excess risk in one population subgroup, we found little or no evidence of an association between smoking and either glioma or meningioma.
关于吸烟与胶质瘤或脑膜瘤之间的关联，证据存在矛盾。我们的目的是为这些可能的关联提供进一步的证据。
我们在加拿大的三个城市，蒙特利尔、渥太华和温哥华开展了一系列病例对照研究。该研究纳入了166例胶质瘤患者、93例脑膜瘤患者以及648名基于人群的对照。收集了吸烟的终生史并计算了各种吸烟指数。采用多变量逻辑回归来估计吸烟与这两种脑肿瘤之间的比值比（OR）。
对于所有吸烟者或累积吸烟超过15包年（（每天吸烟包数）×年数）的吸烟者，吸烟与每种脑肿瘤之间的校正OR均未显著升高。我们检验了吸烟与几个社会人口学变量之间的相互作用；吸烟与教育程度对胶质瘤风险的相互作用显著，吸烟在低教育程度受试者中的OR升高，而在高教育程度受试者中的OR低于1。
除了一个人群亚组中存在无法解释且可能是人为造成的额外风险外，我们几乎没有发现吸烟与胶质瘤或脑膜瘤之间存在关联的证据。
