Zhong Ping, Lin Yiting, Chen Ting
BE and Phase I Clinical Trial Center, The First Affiliated Hospital of Xiamen University, Xiamen, People's Republic of China.
Department of Respiratory and Critical Care Medicine, Xiamen Haicang Hospital, Xiamen, People's Republic of China.
Chin Neurosurg J. 2021 Nov 1;7(1):45. doi: 10.1186/s41016-021-00261-1.
Whether smoking is related to a decreased risk of meningioma in women is still controversial. We conducted a systematic review and meta-analysis examining the association between smoking and risk of meningiomas in women.
Two authors independently performed a systematic literature review in the PubMed, Cochrane Library, and EMBASE databases. We identified case-control and cohort studies quantifying associations between smoking and risk of meningioma in women. A meta-analysis by pooling studies was performed according to the multivariate-adjusted risk estimates and 95% confidence intervals (CIs) preferentially. We further conducted additional subgroup and sensitivity analyses to explore possible explanations of the results.
A total of seven observational studies were included, with a total of 2132 female patients diagnosed with meningiomas. Ever smoking was associated with a significantly reduced risk of meningioma in women, with pooled odds ratio (OR) of 0.83 (95% CI 0.70-0.98). Similar findings were noted for current (OR 0.78, 95% CI 0.66-0.93) and past (OR 0.82, 95% CI 0.71-0.94) smokers. However, considering the areas, the OR of ever smoking was 0.77 (95% CI 0.68-0.87) in three American studies, but 0.99 (95% CI 0.73-1.35) in four studies conducted in other countries.
Based on limited epidemiological evidence, a decreased risk of meningioma in women smokers was only observed in American studies rather than studies conducted in other countries.
吸烟是否与女性脑膜瘤风险降低相关仍存在争议。我们进行了一项系统评价和荟萃分析，以研究吸烟与女性脑膜瘤风险之间的关联。
两位作者独立在PubMed、Cochrane图书馆和EMBASE数据库中进行系统文献检索。我们纳入了量化吸烟与女性脑膜瘤风险之间关联的病例对照研究和队列研究。优先根据多变量调整后的风险估计值和95%置信区间（CI）对纳入研究进行荟萃分析。我们进一步进行了额外的亚组分析和敏感性分析，以探索结果的可能解释。
共纳入7项观察性研究，总计2132例被诊断为脑膜瘤的女性患者。曾经吸烟与女性脑膜瘤风险显著降低相关，汇总比值比（OR）为0.83（95%CI 0.70-0.98）。当前吸烟者（OR 0.78，95%CI 0.66-0.93）和既往吸烟者（OR 0.82，95%CI 0.71-0.94）也有类似发现。然而，考虑地区因素，在美国的3项研究中，曾经吸烟的OR为0.77（95%CI 0.68-0.87），而在其他国家进行的4项研究中为0.99（95%CI 0.73-1.35）。
基于有限的流行病学证据，仅在美国的研究中观察到女性吸烟者脑膜瘤风险降低，而非在其他国家进行的研究中。
