Duncan J S, Angell J W, Carter S D, Evans N J, Sullivan L E, Grove-White D H
Department of Epidemiology and Population Health, Institute of Infection and Global Health, University of Liverpool, Leahurst Campus, Neston, Wirral CH64 7TE, UK.
Department of Epidemiology and Population Health, Institute of Infection and Global Health, University of Liverpool, Leahurst Campus, Neston, Wirral CH64 7TE, UK.
Vet J. 2014 Sep;201(3):265-8. doi: 10.1016/j.tvjl.2014.06.007. Epub 2014 Jun 10.
The novel sheep disease, contagious ovine digital dermatitis (CODD) was first described in the UK in 1997. The disease is characterised by severe lameness associated with initial inflammation at the coronary band, followed by progressive separation of the hoof capsule from the underlying tissue. On microbiological examination, treponeme bacteria have been frequently isolated from cases of CODD, including treponemes phylogenetically identical to those associated with bovine digital dermatitis (BDD). Dichelobacter nodosus and Fusobacterium necrophorum have also been isolated from CODD lesions although their role in the pathogenesis remains uncertain. While epidemiological data indicate that the prevalence of CODD is increasing in the UK, the routes of transmission and associated risk factors have not been clearly elucidated. Evidenced-based treatment trials indicate that parenteral administration of long-acting amoxicillin is an efficacious treatment for CODD, while anecdotal evidence suggests other antibiotics, given locally and/or parenterally, may also be beneficial. Further microbiological and epidemiological research is urgently required to develop sustainable control strategies, including the development of vaccines and appropriate biosecurity and farm management protocols. In this review current knowledge of the clinical, aetiological, and epidemiological aspects of CODD is assessed as well as approaches to its control.
新型绵羊疾病——传染性羊蹄部皮炎（CODD）于1997年在英国首次被描述。该疾病的特征是严重跛行，最初与冠状带炎症有关，随后蹄壳与下方组织逐渐分离。在微生物学检查中，经常从CODD病例中分离出密螺旋体细菌，包括与牛蹄部皮炎（BDD）相关的系统发育相同的密螺旋体。坏死梭杆菌和坏死杆菌也已从CODD病变中分离出来，但其在发病机制中的作用仍不确定。虽然流行病学数据表明CODD在英国的患病率正在上升，但其传播途径和相关风险因素尚未明确阐明。循证治疗试验表明，长效阿莫西林的肠胃外给药是治疗CODD的有效方法，而轶事证据表明，局部和/或肠胃外给予的其他抗生素也可能有益。迫切需要进一步开展微生物学和流行病学研究，以制定可持续的控制策略，包括开发疫苗以及制定适当的生物安全和农场管理方案。在这篇综述中，评估了目前关于CODD临床、病因和流行病学方面的知识以及其控制方法。
