Zhong Yuan, Zhang Ruiting, Li Kai, Qi Rongfeng, Zhang Zhiqiang, Huang Qingling, Lu Guangming
Department of Medical Imaging, Jinling Hospital, Clinical school of Medical College, Nanjing University, Nanjing, PR China School of Psychology, Nanjing Normal University, Nanjing, PR China.
School of Psychology, Nanjing Normal University, Nanjing, PR China.
Acta Radiol. 2015 Jun;56(6):746-53. doi: 10.1177/0284185114537927. Epub 2014 Jun 27.
Post-traumatic stress disorder (PTSD) is often characterized by region-specific brain activation/deactivation and functional abnormalities in corticolimbic circuitry, as elucidated by task-dependent functional neuroimaging. However, little is known about the abnormalities in the local coherence of cortical and subcortical activity occurring during the resting state.
To evaluate the functional discrepancy of local coherence between cortical and subcortical regions in PTSD patients using resting-state functional magnetic resonance imaging (fMRI).
Resting-state fMRI (RS-fMRI) was performed on 14 outpatients with PTSD, along with 14 age- and sex-matched normal control subjects. Regional homogeneity (ReHo), a measurement of the coherence of spontaneous RS-fMRI signal oscillations within spatially neighboring voxels, was examined.
Compared with the normal controls, PTSD patients showed increased local coherence in subcortical regions, including amygdala, hippocampus, thalamus, and putamen, and decreased local coherence in cortical regions, including medial prefrontal cortex and dorsolateral prefrontal cortex. Moreover, a correlation analysis of the ReHo measurement versus the severity of the disorder was performed, and highly positive correlation were observed in the right amygdala.
The present study identified a functional discrepancy of local coherence between cortical and subcortical regions in PTSD patients compared with normal controls. The findings revealed that resting-state abnormalities might lead to further improvement of the understanding of the neural substrates of cognitive impairment and symptoms in PTSD.
创伤后应激障碍（PTSD）通常表现为特定区域的大脑激活/失活以及皮质边缘回路中的功能异常，这已通过任务依赖性功能神经影像学得以阐明。然而，对于静息状态下皮质和皮质下活动的局部一致性异常却知之甚少。
使用静息态功能磁共振成像（fMRI）评估PTSD患者皮质和皮质下区域之间局部一致性的功能差异。
对14名PTSD门诊患者以及14名年龄和性别匹配的正常对照者进行静息态fMRI（RS-fMRI）检查。检测区域一致性（ReHo），这是一种对空间相邻体素内自发RS-fMRI信号振荡一致性的测量方法。
与正常对照组相比，PTSD患者在包括杏仁核、海马体、丘脑和壳核在内的皮质下区域表现出局部一致性增加，而在包括内侧前额叶皮质和背外侧前额叶皮质在内的皮质区域表现出局部一致性降低。此外，对ReHo测量值与疾病严重程度进行了相关性分析，在右侧杏仁核中观察到高度正相关。
本研究确定了PTSD患者与正常对照组相比，皮质和皮质下区域之间局部一致性的功能差异。研究结果表明，静息态异常可能有助于进一步加深对PTSD认知障碍和症状神经基础的理解。
