Idiz Oguz, Aysan Erhan, Firat Deniz, Ersoy Yeliz Emine, Cengiz Merve Busra, Akbulut Huseyin, Isık Arda, Muslumanoglu Mahmut
Department of General Surgery, Bezmialem University, İstanbul, Turkey.
Department of General Surgery, Erzincan University, Erzincan, Turkey.
Med Sci Monit. 2014 Jun 28;20:1090-4. doi: 10.12659/MSM.890460.
We evaluated the effects of local flax seed oil and glycerol application for reducing adhesion formation after thyroidectomy.
We randomly assigned 18 female Wistar albino rats (median weight: 275 g, median age: 4.5 mth) to 3 groups: 0.1 ml 0.9% NaCl, glycerol, and flax seed oil were sprayed in a perithyroidal area after thyroidectomy operation on all animals as anti-adhesive barriers. Rats were sacrificed on the postoperative 14th day and adhesions were evaluated macroscopically and microscopically.
The median macroscopic adhesion score was 3.0±0.0 in the 0.9% NaCl group, 1.33±0.52 in the glycerol group, and 1.67±0.53 in the flax seed oil group. The median histopathological fibrosis scores were 2.33±0.82, 0.67±0.52, and 0.83±0.75, respectively. Both glycerol and flaxseed oil group macroscopic and microscopic scores were significantly lower than the 0.9% NaCl group (p<0.05). There was no significant difference among the groups (p>0.05).
Glycerol and flax seed oil both decrease the incidence of post-thyroidectomy adhesion in rats, but glycerol is more effective.
我们评估了局部应用亚麻籽油和甘油对减少甲状腺切除术后粘连形成的效果。
我们将18只雌性Wistar白化大鼠（体重中位数：275克，年龄中位数：4.5个月）随机分为3组：所有动物在甲状腺切除术后，于甲状腺周围区域喷洒0.1毫升0.9%氯化钠、甘油和亚麻籽油作为抗粘连屏障。术后第14天处死大鼠，对粘连情况进行宏观和微观评估。
0.9%氯化钠组的宏观粘连评分中位数为3.0±0.0，甘油组为1.33±0.52，亚麻籽油组为1.67±0.53。组织病理学纤维化评分中位数分别为2.33±0.82、0.67±0.52和0.83±0.75。甘油组和亚麻籽油组的宏观和微观评分均显著低于0.9%氯化钠组（p<0.05）。各组之间无显著差异（p>0.05）。
甘油和亚麻籽油均可降低大鼠甲状腺切除术后粘连的发生率，但甘油更有效。
