甘油与五硼酸钠制剂对预防术后腹膜粘连形成的作用
Effects of Glycerol and Sodium Pentaborate Formulation on Prevention of Postoperative Peritoneal Adhesion Formation.
作者信息
Aysan Erhan, Sahin Fikrettin, Catal Ruzgar, Javadov Mirkhaliq, Cumbul Alev
机构信息
Yeditepe University, Faculty of Medicine, Department of General Surgery, Istanbul, Turkey.
Yeditepe University, Faculty of Engineering, Department of Genetic and Bioengineering, Istanbul, Turkey.
出版信息
Obstet Gynecol Int. 2020 Apr 6;2020:3679585. doi: 10.1155/2020/3679585. eCollection 2020.
BACKGROUND
Postoperative peritoneal adhesions (PPA) are a serious problem for abdominal surgery. An effective remedy has not been found yet. New formulation of glycerol and sodium pentaborate may be able to solve the problem.
METHOD
Female Wistar albino rats were randomly assigned into four equal groups. The adhesion model was created on the caecum anterior wall and covered with 2 ml 0.9% NaCl, 3% glycerol, 3% sodium pentaborate, and 3% glycerol plus 3% sodium pentaborate solutions in the groups, respectively. Two weeks later, the rats were sacrificed. PPA were graded macroscopically and microscopically.
RESULTS
Total adhesion scores of the 3% glycerol + 3% sodium pentaborate group were statistically different from the other groups for macroscopic and also microscopic evaluations ( < 0.001).
CONCLUSION
3% glycerol plus 3% sodium pentaborate as a new formulation has preventive effects on PPA with a synergistic mechanism.
背景
术后腹膜粘连（PPA）是腹部手术面临的一个严重问题。目前尚未找到有效的解决方法。甘油和硼酸钠的新配方或许能够解决这一问题。
方法
将雌性Wistar白化大鼠随机分为四组，每组数量相等。在盲肠前壁建立粘连模型，然后分别在各组覆盖2毫升0.9%氯化钠溶液、3%甘油溶液、3%硼酸钠溶液以及3%甘油加3%硼酸钠溶液。两周后，处死大鼠。对术后腹膜粘连进行宏观和微观分级。
结果
对于宏观和微观评估，3%甘油 + 3%硼酸钠组的总粘连评分与其他组相比均有统计学差异（<0.001）。
结论
作为一种新配方，3%甘油加3%硼酸钠对术后腹膜粘连具有预防作用，其机制为协同作用。
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