比较脉冲染料激光（PDL）和光动力疗法（PDT）治疗儿童面部葡萄酒色斑（PWS）胎记。
Comparison of pulsed dye laser (PDL) and photodynamic therapy (PDT) for treatment of facial port-wine stain (PWS) birthmarks in pediatric patients.
机构信息
Laser Plastic and Aesthetic Center, Liuhuaqiao Hospital, Guangzhou, China.
Department of Plastic and Reconstructive Surgery, Nanfang Hospital of Southern Medical University, Guangzhou, China.
出版信息
Photodiagnosis Photodyn Ther. 2014 Dec;11(4):491-7. doi: 10.1016/j.pdpdt.2014.06.004. Epub 2014 Jun 25.
BACKGROUND
Vascular-acting photodynamic therapy (PDT) might be an alternative approach for treating port wine stain (PWS) birthmarks, but the usefulness of PDT for pediatric patients has not been fully investigated.
STUDY DESIGN
Medical records of pediatric patients (3-10 years old) with red and purple facial PWS were analyzed. Clinical outcomes after one session of PDL (585 nm, 4.8-6.5 J/cm(2)) and PDT (Hemoporfin - 3.5mg/kg, copper vapour laser - 120 J/cm(2)) were compared.
RESULTS
The rate of excellent response in PDT group was significantly higher than that in PDL group (25.0% vs 10.9%). For red lesions there was no significant difference in overall response between PDL and PDT group, but for purple lesions the overall response rate of PDT group was significantly higher than that of PDL group (93.0% vs 75.6%). Lesions located at the forehead, cheek and jaw regions showed better responses to PDT. Incidences of pigmentation and scar formation in PDT group were significantly lower than PDL group (8.3% vs 21.1%).
CONCLUSION
This study suggests that PDT is safe and effective for treating facial PWS of childhood patients.
背景
血管作用光动力疗法（PDT）可能是治疗葡萄酒色斑（PWS）胎记的一种替代方法，但 PDT 对儿科患者的有效性尚未得到充分研究。
研究设计
分析了 3-10 岁面部有红色和紫色 PWS 的儿科患者的病历。比较了单次 PDL（585nm，4.8-6.5J/cm2）和 PDT（血卟啉单甲醚 - 3.5mg/kg，铜蒸气激光 - 120J/cm2）后的临床效果。
结果
PDT 组的优良反应率明显高于 PDL 组（25.0% vs 10.9%）。对于红色病变，PDL 和 PDT 组的总体反应无显著差异，但对于紫色病变，PDT 组的总体反应率明显高于 PDL 组（93.0% vs 75.6%）。位于额部、颊部和下颌部的病变对 PDT 反应更好。PDT 组色素沉着和瘢痕形成的发生率明显低于 PDL 组（8.3% vs 21.1%）。
结论
本研究表明 PDT 治疗儿童面部 PWS 是安全有效的。
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