Liu Xu, Yang Lihua, Zhang Qian, Yang Fengjuan, Jiang Xian
Department of Dermatology, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
Clin Cosmet Investig Dermatol. 2023 Jun 28;16:1667-1675. doi: 10.2147/CCID.S418019. eCollection 2023.
Port-wine birthmark (PWB) are congenital vascular malformations that commonly occur on the face and neck, with an incidence of 0.3-0.5% in the general population, causing significant negative psychological effects and economic burden to patients. Nevertheless, amidst the plethora of different treatment methods for PWB, choosing the option that best suits the patient's need can be a challenge. In recent years, traditional treatment methods for PWB have been replaced by new therapies, and radioactive nuclide patch therapy is one of them. A panel of experts sought to describe herein 4 clinical cases, illustrating the PDT can demonstrate good precision and efficacy in the treatment of PWB. The research findings show the 4 patients in this group had a history of treatment with radioactive isotope patches. After 2-3 sessions of HMME-PDT, all cases achieved satisfactory results, the color of the red skin lesions significantly faded, and the area of the lesions decreased noticeably. Superficial tissue ultrasound showed a reduction in lesion thickness before and after treatment. In summary, for cases where the efficacy of PWB treatment with radioactive isotope patches is inadequate, Photodynamic therapy (PDT) can be used as a treatment reference.
葡萄酒色斑（PWB）是一种先天性血管畸形，常见于面部和颈部，在普通人群中的发病率为0.3-0.5%，给患者带来显著的负面心理影响和经济负担。然而，在众多不同的PWB治疗方法中，选择最适合患者需求的方法可能具有挑战性。近年来，PWB的传统治疗方法已被新疗法所取代，放射性核素敷贴疗法就是其中之一。一组专家在此描述4例临床病例，说明光动力疗法（PDT）在PWB治疗中可显示出良好的精准度和疗效。研究结果显示，该组4例患者均有放射性同位素敷贴治疗史。经过2-3次的血卟啉单甲醚-光动力疗法（HMME-PDT）治疗后，所有病例均取得满意效果，红色皮损颜色明显变淡，皮损面积显著减小。浅表组织超声显示治疗前后皮损厚度有所降低。总之，对于放射性同位素敷贴治疗PWB疗效不佳的病例，光动力疗法（PDT）可作为一种治疗参考。
