正常和肿瘤干细胞中的活性氧物种。
Reactive oxygen species in normal and tumor stem cells.
作者信息
Zhou Daohong, Shao Lijian, Spitz Douglas R
机构信息
Division of Radiation Health, Department of Pharmaceutical Sciences, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Division of Radiation Health, Department of Pharmaceutical Sciences, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
出版信息
Adv Cancer Res. 2014;122:1-67. doi: 10.1016/B978-0-12-420117-0.00001-3.
Reactive oxygen species (ROS) play an important role in determining the fate of normal stem cells. Low levels of ROS are required for stem cells to maintain quiescence and self-renewal. Increases in ROS production cause stem cell proliferation/differentiation, senescence, and apoptosis in a dose-dependent manner, leading to their exhaustion. Therefore, the production of ROS in stem cells is tightly regulated to ensure that they have the ability to maintain tissue homeostasis and repair damaged tissues for the life span of an organism. In this chapter, we discuss how the production of ROS in normal stem cells is regulated by various intrinsic and extrinsic factors and how the fate of these cells is altered by the dysregulation of ROS production under various pathological conditions. In addition, the implications of the aberrant production of ROS by tumor stem cells for tumor progression and treatment are also discussed.
活性氧（ROS）在决定正常干细胞的命运中起着重要作用。干细胞维持静止和自我更新需要低水平的ROS。ROS产生的增加以剂量依赖的方式导致干细胞增殖/分化、衰老和凋亡，从而导致它们耗竭。因此，干细胞中ROS的产生受到严格调控，以确保它们在生物体的寿命期间有能力维持组织稳态并修复受损组织。在本章中，我们讨论正常干细胞中ROS的产生如何受到各种内在和外在因素的调节，以及在各种病理条件下ROS产生失调如何改变这些细胞的命运。此外，还讨论了肿瘤干细胞异常产生ROS对肿瘤进展和治疗的影响。
Zotero 插件