8-酰基和8-烷基异康普汀A类似物的抗原虫活性。

Antiprotozoal activity of 8-acyl and 8-alkyl incomptine A analogs.

作者信息

Bautista Elihú, Calzada Fernando, López-Huerta Fabiola A, Yépez-Mulia Lilian, Ortega Alfredo

机构信息

Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, C.P. 04510 México D.F., Mexico.

Unidad de Investigación Médica en Farmacología, UMAE Hospital de Especialidades, 2° Piso CORSE, Centro Médico Nacional Siglo XXI, IMSS, Av. Cuahutemoc 330, Col. Doctores, C.P. 06725 México D.F., Mexico.

出版信息

Bioorg Med Chem Lett. 2014 Aug 1;24(15):3260-2. doi: 10.1016/j.bmcl.2014.06.017. Epub 2014 Jun 16.

DOI:10.1016/j.bmcl.2014.06.017

PMID:24974343

Abstract

The activities of 11 C-8-O-acyl and alkyl analogs of the antiprotozoal sesquiterpene lactone, incomptine A (1) against Entamoeba histolytica and Giardia lamblia, were determined. Here, the effects of different lengths and amounts of branching of the acyl and alkyl groups on the antiprotozoal activity of the synthesized incomptine A-analogs are reported.

摘要

测定了抗原生动物倍半萜内酯类化合物 incomptine A（1）的 11 种 C-8-O-酰基和烷基类似物对溶组织内阿米巴和蓝氏贾第鞭毛虫的活性。在此，报道了酰基和烷基不同长度及支链数量对合成的 incomptine A 类似物抗原生动物活性的影响。