Lei Q, Peng W N, You H, Hu Z P, Lu W
Pharmazie. 2014 Jun;69(6):448-54.
Statins are commonly prescribed lipid-lowering medications that significantly reduce the risk of cardiovascular events. In addition to their ability to lower cholesterol by affecting the rate-limiting step in cholesterol biosynthesis, statins also have anti-inflammatory, immunomodulatory, antioxidant, antiapoptotic, and antiplatelet effects. Because of these pleiotropic abilities, statins may have some beneficial effects on neurologic diseases, including cerebrovascular disease, neurodegenerative disease, multiple sclerosis, and brain tumors. Although statins are a well-tolerated class of drugs, they also have potential adverse effects (AEs). A growing body of evidence indicates that statins may have potential negative effects on nervous system-associated diseases, including myopathies, peripheral neuropathy, intracerebral hemorrhage (ICH), and other diseases of the central nervous system (e.g., cognitive impairment, depression, sleep disorders, nightmare, and headache). Clinicians, especially neurologists, should be aware of the potential risk of neuropathy in patients who take statins.
他汀类药物是常用的降脂药物，可显著降低心血管事件的风险。除了通过影响胆固醇生物合成的限速步骤来降低胆固醇的能力外，他汀类药物还具有抗炎、免疫调节、抗氧化、抗凋亡和抗血小板作用。由于这些多效性能力，他汀类药物可能对神经系统疾病有一些有益作用，包括脑血管疾病、神经退行性疾病、多发性硬化症和脑肿瘤。虽然他汀类药物是一类耐受性良好的药物，但它们也有潜在的不良反应（AE）。越来越多的证据表明，他汀类药物可能对神经系统相关疾病有潜在的负面影响，包括肌病、周围神经病变、脑出血（ICH）和其他中枢神经系统疾病（如认知障碍、抑郁、睡眠障碍、噩梦和头痛）。临床医生，尤其是神经科医生，应该意识到服用他汀类药物的患者发生神经病变的潜在风险。
