Zhao Tie, He Jun, Wang Xiaoxue, Ma Bingzhi, Wang Xiaoxing, Zhang Lei, Li Ping, Liu Ning, Lu Jin, Zhang Xianglin
Pharmacy Department, China-Japan Friendship Hospital, Beijing, China.
Department of Pharmacology, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.
J Pharm Biomed Anal. 2014 Sep;98:311-20. doi: 10.1016/j.jpba.2014.05.019. Epub 2014 Jun 12.
Radix Actinidia chinensis Planch is a traditional Chinese herb, and its decotion had been widely used clinically to treat several types of cancer. In our study, the phenolic compounds constituting the major water soluble components of Radix A. chinensis were profiled and characterized by ultraperformance liquid chromatography electrospray ionization tandem mass spectrometry. A total of 50 compounds were identified or tentatively characterized, including caffeic acid, p-coumaric acid, 29 catechin derivatives, 12 quinic acid derivatives and 7 coumarin derivatives. Most of the identified compounds were firstly reported from A. chinensis. Among them, scopoletin, scoplin, isofraxoside and quinic acid derivatives have not ever been reported from genus Actinidia previously. These phenolic compounds might be responsible for the antitumor activity of the water extract of radix A. chinensis, and the established analytical method could be applied to further study of quality evaluation and active components of Radix A. chinensis.
中华猕猴桃根是一种传统的中草药，其煎剂在临床上已被广泛用于治疗多种类型的癌症。在我们的研究中，采用超高效液相色谱电喷雾电离串联质谱法对构成中华猕猴桃根主要水溶性成分的酚类化合物进行了分析和表征。共鉴定或初步表征了50种化合物，包括咖啡酸、对香豆酸、29种儿茶素衍生物、12种奎宁酸衍生物和7种香豆素衍生物。大多数已鉴定的化合物首次从中华猕猴桃中报道。其中，东莨菪素、东莨菪苷、异秦皮苷和奎宁酸衍生物此前从未在猕猴桃属植物中报道过。这些酚类化合物可能是中华猕猴桃根水提取物抗肿瘤活性的原因，所建立的分析方法可应用于中华猕猴桃根质量评价和活性成分的进一步研究。
