University of Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297, F-33000 Bordeaux, France; CNRS, UMR 5297, F-33000 Bordeaux, France.
University of Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297, F-33000 Bordeaux, France; CNRS, UMR 5297, F-33000 Bordeaux, France; Imagine Optic, 18 rue Charles de Gaulle, 91400 Orsay, France.
Curr Opin Chem Biol. 2014 Jun;20:120-6. doi: 10.1016/j.cbpa.2014.05.017. Epub 2014 Jun 27.
Progresses in microscopy have often led to major discoveries in neuroscience, and the recent advent of super-resolution microscopy is no exception. In this review, we will show how imaging has advanced our modern vision of synaptic function. More particularly, we will emphasize how novel nanoscopy techniques have helped in deciphering the organization of post-synaptic proteins, offering new insight into the mechanism of synaptic transmission.
显微镜技术的进步常常会带来神经科学领域的重大发现,最近超分辨率显微镜的出现也不例外。在这篇综述中,我们将展示成像技术如何推动了我们对突触功能的现代认识。更具体地说,我们将强调新的纳米成像技术如何帮助我们破译突触后蛋白的组织,为突触传递的机制提供新的见解。