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新世界猴科动物中的抗坏血酸:物种差异及应激源对抗坏血酸代谢的影响

Ascorbic acid in a New World monkey family: species difference and influence of stressors on ascorbic acid metabolism.

作者信息

Flurer C I, Zucker H

机构信息

Institut für Physiologie, Physiologische Chemie und Ernährungsphysiologie, Tierärztlichen Fakultät, Ludwig-Maximilians-Universität München, FRG.

出版信息

Z Ernahrungswiss. 1989 Mar;28(1):49-55. doi: 10.1007/BF02025565.

DOI:10.1007/BF02025565
PMID:2497592
Abstract

Like other simian primates, the New World monkey Callithrix jacchus, marmoset, and Saguinus fuscicollis, tamarin, require ascorbic acid as an essential nutrient. For adult marmosets, a daily intake of 15 mg/kg metabolic body weight was found to be necessary to obtain a serum level above the kidney threshold. A survey of the serum ascorbic acid level of marmosets and tamarins in a breeding colony resulted in a vast divergence between the two species, indicating a higher ascorbic acid requirement for tamarins. Unaccustomed trial conditions or additional stressors resulted in a higher catabolism of ascorbic acid to CO2 in both species, measured with 14C labeled material, compared to a higher rate of renal excretion when the animals were accustomed to the metabolic cage. These isotope excretion studies suggest a different metabolic behavior of ascorbic acid in the two species. This is supposedly caused by a higher sensitivity of the tamarins when subjected to the same conditions as marmosets.

摘要

与其他猿猴灵长类动物一样,新世界猴绢毛猴(Callithrix jacchus)和褐颈柽柳猴(Saguinus fuscicollis)需要将抗坏血酸作为必需营养素。对于成年绢毛猴而言,发现每日摄入15毫克/千克代谢体重对于使血清水平高于肾脏阈值是必要的。对一个繁殖群体中的绢毛猴和柽柳猴的血清抗坏血酸水平进行的一项调查显示,这两个物种之间存在巨大差异,表明柽柳猴对抗坏血酸的需求量更高。与动物习惯代谢笼时较高的肾脏排泄率相比,不习惯的试验条件或额外的应激源导致这两个物种中抗坏血酸分解代谢为二氧化碳的量更高,这是通过用14C标记的物质测量得出的。这些同位素排泄研究表明抗坏血酸在这两个物种中的代谢行为不同。这可能是由于柽柳猴在与绢毛猴相同的条件下时具有更高的敏感性所致。

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