Shinki T, Shiina Y, Takahashi N, Tanioka Y, Koizumi H, Suda T
Biochem Biophys Res Commun. 1983 Jul 29;114(2):452-7. doi: 10.1016/0006-291x(83)90801-x.
Compared to most mammals, the marmoset, a new world monkey, requires particularly large amounts of vitamin D to maintain normal growth. We compared serum concentrations of vitamin D metabolites in marmosets with rhesus monkeys and humans. The circulating levels of 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25(OH)2D3] in marmosets were 4 to 10 times higher than those in rhesus monkeys and humans. But none of the marmosets exhibited hypercalcemia. In two marmosets which had suffered bone fractures, the 1 alpha,25(OH)2D3 levels were particularly elevated. These results suggest that the marmoset has an end-organ resistance to 1 alpha,25(OH)2D3.
与大多数哺乳动物相比，新世界猴狨猴维持正常生长需要特别大量的维生素D。我们比较了狨猴与恒河猴和人类血清中维生素D代谢物的浓度。狨猴体内1α,25 - 二羟基维生素D3 [1α,25(OH)2D3]的循环水平比恒河猴和人类高4至10倍。但没有一只狨猴出现高钙血症。在两只发生过骨折的狨猴中，1α,25(OH)2D3水平特别升高。这些结果表明，狨猴对1α,25(OH)2D3存在终末器官抵抗。
