Kostaki D, Antonini A, Peris K, Fargnoli M C
Department of Dermatology University of L'Aquila, L'Aquila, Italy -
G Ital Dermatol Venereol. 2014 Oct;149(5):567-72. Epub 2014 Jun 30.
Cutaneous malignancies have been significantly associated with autoimmune connective tissue diseases (ACTDs). This review focuses on the current state of knowledge on skin cancer risk in the most prevalent ACTDs in dermatology including lupus erythematosus, scleroderma, dermatomyositis and Sjögren syndrome. Potential pathogenetic mechanisms for the association between ACTDs and malignancy involve disease-related impairment of immune system, sustained cutaneous inflammation, drug-associated immune suppression and increased susceptibility to acquired viral infections. An additional causal role might be played by environmental factors such as UV exposure and smoking. The occurrence of skin cancer can have a profound impact on the already compromised quality of life of ACTD patients. Therefore, effective screening and monitoring strategies are essential for ACTD patients as early detection and prompt therapeutic intervention can reduce morbidity and mortality in these patients.
皮肤恶性肿瘤与自身免疫性结缔组织病（ACTDs）显著相关。本综述聚焦于皮肤科最常见的ACTDs（包括红斑狼疮、硬皮病、皮肌炎和干燥综合征）中皮肤癌风险的当前知识状态。ACTDs与恶性肿瘤之间关联的潜在发病机制包括与疾病相关的免疫系统损害、持续性皮肤炎症、药物相关的免疫抑制以及对获得性病毒感染易感性增加。环境因素如紫外线暴露和吸烟可能也起到额外的因果作用。皮肤癌的发生会对ACTD患者本已受损的生活质量产生深远影响。因此，有效的筛查和监测策略对ACTD患者至关重要，因为早期发现和及时的治疗干预可降低这些患者的发病率和死亡率。
