莱姆病中心脏迷走神经张力的呼吸调节
Respiratory modulation of cardiac vagal tone in Lyme disease.
作者信息
Puri Basant K, Shah Mussadiq, Monro Jean A, Kingston Michele C, Julu Peter Oo
机构信息
Basant K Puri, Department of Medicine, Imperial College London, Hammersmith Hospital, London W12 0HS, United Kingdom.
出版信息
World J Cardiol. 2014 Jun 26;6(6):502-6. doi: 10.4330/wjc.v6.i6.502.
AIM
To conduct the first systematic test of the hypothesis that modulation of cardiac vagal tone is impaired in Lyme disease.
METHODS
The response of cardiac vagal tone to respiratory modulation was measured in 18 serologically positive Lyme disease patients and in 18 controls.
RESULTS
The two groups were matched in respect of age, sex, body mass, mean arterial blood pressure, mean resting heart rate and mean resting cardiac vagal tone. The mean maximum cardiac vagal tone during deep breathing in the Lyme disease patients [11.2 (standard error 1.3)] was lower than in the matched controls [16.5 (standard error 1.7); P = 0.02].
CONCLUSION
Respiratory modulation of cardiac vagal tone is impaired in Lyme disease, which suggests that Lyme disease may directly affect the vagus nerve or the brainstem.
目的
对莱姆病中心脏迷走神经张力调节受损这一假说进行首次系统性检验。
方法
测量了18例血清学阳性莱姆病患者及18例对照者心脏迷走神经张力对呼吸调节的反应。
结果
两组在年龄、性别、体重、平均动脉血压、平均静息心率及平均静息心脏迷走神经张力方面相匹配。莱姆病患者深呼吸时的平均最大心脏迷走神经张力[11.2（标准误1.3）]低于匹配的对照组[16.5（标准误1.7）；P = 0.02]。
结论
莱姆病中心脏迷走神经张力的呼吸调节受损，这表明莱姆病可能直接影响迷走神经或脑干。
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