Grossman P, Kollai M
Psychophysiology Research Group, University of Freiburg, Germany.
Psychophysiology. 1993 Sep;30(5):486-95. doi: 10.1111/j.1469-8986.1993.tb02072.x.
Respiratory sinus arrhythmia (RSA) is frequently employed as an intra- and interindividual index of cardiac parasympathetic tone, although the relationship of RSA to interindividual differences in cardiac vagal tone remains questionable. Our study examined between- and within-subject relations among RSA, cardiac vagal tone, and respiratory parameters. Twenty-nine young adults performed two sessions of tasks under no medication and single and double autonomic blockade (intravenously administered propranolol and atropine). Parasympathetic tone was determined from heart period responses to complete vagal blockade. Results indicated the following. Resting RSA does not accurately predict individual differences in cardiac vagal tone. However, RSA and heart period together do predict such individual differences reasonably well. The relationship between individual variations in RSA and vagal tone is not improved by controlling respiratory parameters. Substantial cardiac vagal activity occurs during inspiration, and intraindividual variations in respiratory measures confound the association between RSA and cardiac vagal tone.
呼吸性窦性心律不齐（RSA）常被用作心脏副交感神经张力的个体内和个体间指标，尽管RSA与心脏迷走神经张力个体差异之间的关系仍存在疑问。我们的研究考察了RSA、心脏迷走神经张力和呼吸参数之间的个体间和个体内关系。29名年轻成年人在未用药以及单次和双重自主神经阻滞（静脉注射普萘洛尔和阿托品）的情况下进行了两阶段任务。通过对完全迷走神经阻滞的心率反应来确定副交感神经张力。结果如下。静息RSA不能准确预测心脏迷走神经张力的个体差异。然而，RSA和心率一起确实能较好地预测此类个体差异。通过控制呼吸参数并不能改善RSA个体差异与迷走神经张力之间的关系。吸气期间会出现大量心脏迷走神经活动，呼吸测量的个体内差异会混淆RSA与心脏迷走神经张力之间的关联。
