1 Department of Pulmonary Medicine, Gulhane Military Medical Academy Haydarpasa Training Hospital, Istanbul, Uskudar, Turkey ; 2 Department of Pulmonary Medicine, Gulhane Military Medical Academy, Ankara, Etlik, Turkey ; 3 Department of Radiology, Gulhane Military Medical Academy Haydarpasa Training Hospital, Istanbul, Uskudar, Turkey ; 4 Department of Infectious Diseases and Clinical Microbiology, Gulhane Military Medical Academy Haydarpasa Training Hospital, Istanbul, Uskudar, Turkey.
J Thorac Dis. 2014 Jun;6(6):706-12. doi: 10.3978/j.issn.2072-1439.2014.03.41.
The aim of this study was to assess the clinical features and high resolution computed tomography (HRCT) findings in smear-negative pulmonary tuberculosis (PTB) and to evaluate the correlation between these parameters and the culture results.
We retrospectively studied 78 active smear-negative PTB patients. They were divided into two groups according to their culture results. The HRCT findings and clinical features at the beginning of the antituberculosis treatment were reviewed.
The mean age was 22.48±3.18 years. Micronodules (87%), large nodules (63%) and centrilobular nodules (62%) were the most common HRCT findings. HRCT findings were observed in the right upper (72%), left upper (56%), right lower (32%), and left lower lobes (29%). Cough (37%) and chest pain (32%) were the most frequent symptoms at presentation.
There were no significant differences in the HRCT findings and clinical features between the two groups. Thus, in cases of smear-negative and culture-negative PTB, the patient with compatible clinical and radiological features should be considered for tuberculosis treatment.
本研究旨在评估菌阴肺结核（PTB）患者的临床特征和高分辨率计算机断层扫描（HRCT）表现，并评估这些参数与培养结果之间的相关性。
我们回顾性研究了 78 例活动性菌阴肺结核患者。根据培养结果将他们分为两组。回顾分析了抗结核治疗开始时的 HRCT 表现和临床特征。
平均年龄为 22.48±3.18 岁。微结节（87%）、大结节（63%）和小叶中心结节（62%）是最常见的 HRCT 表现。HRCT 发现于右肺上叶（72%）、左肺上叶（56%）、右肺下叶（32%）和左肺下叶（29%）。就诊时最常见的症状是咳嗽（37%）和胸痛（32%）。
两组间 HRCT 表现和临床特征无显著差异。因此，对于菌阴和培养阴性的肺结核患者，若临床和影像学特征相符，应考虑进行结核病治疗。
