Kostapanos Michael S, Elisaf Moses S
Michael S Kostapanos, Moses S Elisaf, Department of Internal Medicine, School of Medicine, University of Ioannina, 45110 Ioannina, Greece.
World J Exp Med. 2014 Feb 20;4(1):1-6. doi: 10.5493/wjem.v4.i1.1.
Patients with type 2 diabetes mellitus (T2DM) frequently exhibit macrovascular complications of atherosclerotic cardiovascular (CV) disease. High density lipoproteins (HDL) are protective against atherosclerosis. Low levels of HDL cholesterol (HDL-C) independently contribute to CV risk. Patients with T2DM not only exhibit low HDL-C, but also dysfunctional HDL. Furthermore, low concentration of HDL may increase the risk for the development of T2DM through a decreased β cell survival and secretory function. In this paper, we discuss emerging concepts in the relationship of T2DM with HDL.
2型糖尿病（T2DM）患者常表现出动脉粥样硬化性心血管（CV）疾病的大血管并发症。高密度脂蛋白（HDL）具有抗动脉粥样硬化作用。低水平的高密度脂蛋白胆固醇（HDL-C）独立增加心血管疾病风险。T2DM患者不仅HDL-C水平低，而且HDL功能异常。此外，HDL浓度降低可能通过降低β细胞存活和分泌功能增加T2DM发生风险。在本文中，我们讨论了T2DM与HDL关系中的新观点。
