抗体和自然杀伤细胞识别的人类白细胞抗原Bw4和Bw6表位
Human leukocyte antigen Bw4 and Bw6 epitopes recognized by antibodies and natural killer cells.
作者信息
Lutz Charles T
机构信息
Department of Pathology and Laboratory Medicine and Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, Kentucky, USA.
出版信息
Curr Opin Organ Transplant. 2014 Aug;19(4):436-41. doi: 10.1097/MOT.0000000000000103.
PURPOSE OF REVIEW
To describe the structural basis of human leukocyte antigen (HLA) Bw4 and Bw6 epitopes that are recognized by antibodies and the KIR3DL1 natural killer cell receptor.
RECENT FINDINGS
Molecular modeling and X-ray crystallography have refined our understanding of Bw4 and Bw6. These epitopes had been defined by comparison of HLA allele sequences and by site-directed mutagenesis. Anti-Bw4 and anti-Bw6 antibodies and KIR3DL1 receptors recognize HLA α-1 α-helix residues 77-83 in combination with other HLA regions. The variability of HLA sequences within the 77-83 region and at other sites indicates that the Bw4 epitope is complex. Adding complexity, HLA-bound peptides influence Bw4 and Bw6 epitopes. These structures are recognized by diverse antibodies and KIR3DL1 allotypes. This diversity allowed a Bw4 patient to produce anti-Bw4 antibody without breaking self-tolerance.
SUMMARY
Bw4 and Bw6 epitopes are best regarded as families of related structures that are recognized by a diverse array of antibodies and KIR3DL1 allotypes.
综述目的
描述人类白细胞抗原（HLA）Bw4和Bw6表位的结构基础，这些表位可被抗体及KIR3DL1自然杀伤细胞受体识别。
最新发现
分子建模和X射线晶体学加深了我们对Bw4和Bw6的理解。这些表位已通过HLA等位基因序列比较和定点诱变得以确定。抗Bw4和抗Bw6抗体以及KIR3DL1受体结合HLA α-1螺旋77 - 83位残基及其他HLA区域来识别HLA。77 - 83区域及其他位点的HLA序列变异性表明Bw4表位很复杂。更复杂的是，与HLA结合的肽会影响Bw4和Bw6表位。这些结构可被多种抗体和KIR3DL1同种异型识别。这种多样性使得一名携带Bw4的患者在不打破自身耐受性的情况下产生了抗Bw4抗体。
总结
Bw4和Bw6表位最好被视为相关结构的家族，可被多种抗体和KIR3DL1同种异型识别。
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