Ferrand François Régis, Garcia-Hejl Carine, Moussaid Yassine, Schernberg Antoine, Bidard François-Clément, Pavic Michel, Khenifer Safia, Stoclin Annabelle
Hôpital du Val-de-Grâce, département d'oncologie-radiothérapie, boulevard du Port-Royal, 75005 Paris, France, Institut Gustave Roussy, département d'anesthésie-réanimation, Villejuif, France.
Hôpital du Val-de-Grâce, département de biologie, France.
Bull Cancer. 2014 Jun;101(6):580-92. doi: 10.1684/bdc.2014.1959.
Disseminated intravascular coagulation (DIC) is a complex abnormality of hemostasis with dramatic consequences and long described as associated with tumors. Yet the diagnosis and management of paraneoplastic DIC are poorly defined. The purpose of this paper is to review DIC associated with solid tumors, at the pathophysiological and therapeutic levels in particular. We also report data from a recent retrospective series of patients with DIC in the context of a solid tumor, to illustrate the epidemiological, clinical and prognostic.
弥散性血管内凝血(DIC)是一种复杂的止血异常,具有严重后果,长期以来被认为与肿瘤有关。然而,副肿瘤性DIC的诊断和管理尚不清楚。本文的目的是特别是在病理生理和治疗层面综述与实体瘤相关的DIC。我们还报告了最近一组实体瘤患者DIC回顾性系列的数据,以说明其流行病学、临床和预后情况。