Martinez-Escala M Estela, Curto-Barredo Laia, Carnero Lluïsa, Pujol Ramon M, Giménez-Arnau Ana M
Department of Dermatology, Hospital del Mar, Parc de Salut Mar, Institut Municipal d'Investigació Mèdica, Barcelona, Spain.
Acta Derm Venereol. 2015 Mar;95(3):278-82. doi: 10.2340/00015555-1918.
Cold contact urticaria is the second most common subtype of physical urticaria. Cold stimulation standardized tests are mandatory to confirm the diagnosis. The aim of this study is to define the utility of determining thresholds (critical time and temperature) in assessment of the clinical course of typical acquired cold contact urticaria. Nineteen adult patients (10 women and 9 men; mean age 45 years) were included in the study and the diagnosis was confirmed with the ice-cube test and TempTest 3.0. Patients were treated continuously for 1 year with 20 mg/day rupatadine (anti-H1). Thresholds measurements were made before and after treatment. Improvements in temperature and critical time thresholds were found in the study sample, demonstrating the efficacy of continuous treatment with rupatadine. In most cases association with a clinical improvement was found. We propose an algorithm for the management of acquired cold contact urticaria based on these results.
冷接触性荨麻疹是物理性荨麻疹的第二常见亚型。冷刺激标准化试验对于确诊至关重要。本研究的目的是确定在评估典型获得性冷接触性荨麻疹临床病程中测定阈值（临界时间和温度）的效用。19名成年患者（10名女性和9名男性；平均年龄45岁）纳入本研究，通过冰块试验和TempTest 3.0确诊。患者接受20毫克/天的卢帕他定（抗H1）持续治疗1年。在治疗前后进行阈值测量。研究样本中发现温度和临界时间阈值有所改善，证明了卢帕他定持续治疗的疗效。在大多数情况下发现与临床改善相关。基于这些结果，我们提出了一种获得性冷接触性荨麻疹的管理算法。
