Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité- Universitätsmedizin Berlin, 10117 Berlin, Germany.
Br J Dermatol. 2010 Jan;162(1):198-200. doi: 10.1111/j.1365-2133.2009.09441.x. Epub 2009 Sep 28.
Background Acquired cold urticaria (ACU) is a physical urticaria characterized by local skin reactions after cold exposure. Objective markers of disease severity and activity would be helpful. Unfortunately, such markers are not yet available, even though stimulation time and temperature thresholds are promising candidates. Objectives We assessed and correlated critical temperature thresholds (CTTs) with disease severity and activity in patients with ACU. Methods CTTs were determined in 45 patients with ACU by TempTest-based cold contact stimulation tests (Emo Systems GmbH, Berlin, Germany), and ACU severity and activity were assessed using Likert scales. Results Patients with ACU exhibited mean +/- SEM CTTs of 17 +/- 6 degrees C (range 4-27 degrees C). These thresholds and their changes correlated with the severity (r = 0.53, P < 0.05) and activity of disease (r = 0.64, P < 0.05), respectively. Conclusions These findings indicate that temperature threshold measurements may be used for assessing disease severity and activity as well as the efficacy of therapeutic measures including novel treatment approaches for cold urticaria.
获得性冷荨麻疹（ACU）是一种物理性荨麻疹，其特征是在暴露于寒冷后出现局部皮肤反应。疾病严重程度和活动的客观标志物将很有帮助。不幸的是，即使刺激时间和温度阈值是很有前途的候选标志物，但目前仍没有这样的标志物。目的：我们评估并比较了 ACU 患者的临界温度阈值（CTT）与疾病严重程度和活动的相关性。方法：通过基于 TempTest 的冷接触刺激试验（德国柏林 Emo Systems GmbH）确定了 45 例 ACU 患者的 CTT，并使用李克特量表评估了 ACU 的严重程度和活动。结果：ACU 患者的平均 +/- SEM CTT 为 17 +/- 6°C（范围 4-27°C）。这些阈值及其变化与疾病的严重程度（r = 0.53，P < 0.05）和活动（r = 0.64，P < 0.05）分别相关。结论：这些发现表明，温度阈值测量可用于评估疾病严重程度和活动，以及包括新型冷荨麻疹治疗方法在内的治疗措施的疗效。
