Wijmenga Cisca, Gutierrez-Achury Javier
University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.
J Pediatr Gastroenterol Nutr. 2014 Jul;59 Suppl 1:S4-7. doi: 10.1097/01.mpg.0000450392.23156.10.
In the past few years there has been enormous progress in unraveling the genetic basis of celiac disease (CD). Apart from the well-known association to HLA, there are currently 40 genomic loci associated to CD. Most of these loci show pleiotropic effects across many autoimmune diseases and highlight the importance of a dysregulated immune system in the predisposition to CD. It is still too early, however, to use genetics in clinical practice for predicting individual risk. The major challenge for the future is to translate genetic findings into a better understanding of the underlying disease mechanism and to design new ways to treat CD and prevent its development.
在过去几年中，在揭示乳糜泻（CD）的遗传基础方面取得了巨大进展。除了与HLA的众所周知的关联外，目前有40个与CD相关的基因组位点。这些位点中的大多数在许多自身免疫性疾病中显示出多效性作用，并突出了免疫系统失调在CD易感性中的重要性。然而，在临床实践中使用遗传学来预测个体风险仍为时过早。未来的主要挑战是将遗传研究结果转化为对潜在疾病机制的更好理解，并设计新的方法来治疗CD并预防其发展。
