Vaz Sara O, Franco Catarina, Santos Patrícia, Amaral Raquel
Pediatric Department, Hospital of Divino Espírito Santo of Ponta Delgada, Ponta Delgada - São Miguel, Azores, Portugal.
Dermatology Department, Hospital of Divino Espírito Santo of Ponta Delgada, Ponta Delgada - São Miguel, Azores, Portugal.
BMJ Case Rep. 2018 Jan 4;2018:bcr-2017-222797. doi: 10.1136/bcr-2017-222797.
Coeliac disease (CD) is an autoimmune disease, characterised by a permanent sensitivity to gluten. It is being progressively recognised as a multisystemic disease, with multiple extraintestinal manifestations. Skin conditions (eg, dermatitis herpetiformis) are an example of its manifestations; however, its underlying mechanisms are still not well understood. This article presents three cases of uncommon skin conditions in patients with a history of CD. Two of them concern linear IgA bullous dermatosis and erythema nodosum, which have been described in the literature as having potential associations with CD, though only a few cases were reported. The third case corresponds to pityriasis lichenoides-a rare lymphoproliferative disorder of unknown aetiology-, which has no correlation with CD in the literature reviewed. The authors aim to draw attention to the possibility of CD as a potential predisposing factor for the occurrence of these skin diseases.
乳糜泻（CD）是一种自身免疫性疾病，其特征是对麸质永久性敏感。它正逐渐被认为是一种多系统疾病，具有多种肠外表现。皮肤疾病（如疱疹样皮炎）就是其表现之一；然而，其潜在机制仍未被充分理解。本文介绍了3例有CD病史患者出现的罕见皮肤疾病病例。其中2例涉及线状IgA大疱性皮肤病和结节性红斑，文献中已描述它们可能与CD有关，尽管仅有少数病例报道。第3例是苔藓样糠疹——一种病因不明的罕见淋巴细胞增生性疾病——在所查阅的文献中与CD无相关性。作者旨在提醒人们注意CD作为这些皮肤疾病发生的潜在易感因素的可能性。
