家庭混乱与青少年炎症特征：社会经济地位的调节作用。

Family chaos and adolescent inflammatory profiles: the moderating role of socioeconomic status.

机构信息

From the Department of Pediatrics (H.M.C.S.), Icahn School of Medicine at Mount Sinai, New York, New York; Department of Psychology (L.B.R.), University of British Columbia, Vancouver, BC, Canada; Department of Psychiatry (L.T.F.), St Paul's Hospital, Vancouver, BC, Canada; and Department of Psychology and Cells to Society (C2S) (E.C.), The Center on Social Disparities and Health, Institute for Policy Research, Northwestern University, Evanston, Illinois.

出版信息

Psychosom Med. 2014 Jul-Aug;76(6):460-7. doi: 10.1097/PSY.0000000000000078.

DOI:10.1097/PSY.0000000000000078

PMID:24979577

Abstract

OBJECTIVE

To test whether family chaos influences adolescents' inflammatory profiles and whether adolescents from low socioeconomic status (SES) environments are at higher risk for experiencing adverse inflammatory profiles from living in chaotic family environments.

METHODS

A total of 244 families with an adolescent aged 13 to 16 years participated. Parents completed measures of family SES and family chaos. Both systemic inflammation and stimulated proinflammatory cytokine production in response to bacterial challenge were assessed in adolescents.

RESULTS

Our results suggest that SES moderates the detrimental effect of family chaos on systemic inflammation and interleukin-6 (B = -0.010, standard error [SE] = 0.004, p = .026), but not C-reactive protein (B = 0.009, SE = 0.006, p = .11), and on stimulated proinflammatory cytokine production (B = -0.098, SE = 0.044, p = .026) in adolescents, such that a chaotic family environment is positively associated with greater systemic inflammation and greater stimulated proinflammatory cytokine production in adolescents as family SES declines.

CONCLUSIONS

These findings indicate that living in chaotic family environments places youth who may be vulnerable based on socioeconomic factors at a potentially higher risk for inflammation-related diseases.

摘要

目的

检验家庭混乱是否会影响青少年的炎症指标，以及来自社会经济地位（SES）较低环境的青少年是否因生活在混乱的家庭环境中而更有可能出现不良炎症指标。

方法

共有 244 个有 13 至 16 岁青少年的家庭参与了此项研究。父母完成了 SES 和家庭混乱的测量。青少年的全身炎症和对细菌挑战的促炎细胞因子产生都得到了评估。

结果

我们的结果表明，SES 调节了家庭混乱对全身炎症和白细胞介素-6（B = -0.010，标准误差 [SE] = 0.004，p =.026）的不利影响，但对 C-反应蛋白（B = 0.009，SE = 0.006，p =.11）和刺激后促炎细胞因子的产生（B = -0.098，SE = 0.044，p =.026）没有影响，即家庭环境越混乱，SES 越低的青少年的全身炎症和刺激后促炎细胞因子的产生就越高。