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[饮酒与循环炎症标志物]

[Alcohol consumption and circulating markers of inflammation].

作者信息

Volpato Stefano, Fellin Renato

机构信息

Sezione di Medicina Interna, Gerontologia e Geriatria, Dipartimento di Medicina Clinica e Sperimentale, Università di Ferrara.

出版信息

Recenti Prog Med. 2005 Feb;96(2):102-7.

Abstract

Atherosclerosis, the leading cause of death in western countries, is a multifactiorial condition in which a local and low-grade inflammatory response plays an important role. Elevation in markers of inflammation prospectively defines risk of atherosclerotic complications and predicts all-cause mortality. Alcohol consumption has been related with all-cause mortality and cardiovascular risk with a J-shaped relationship, suggesting that alcohol consumption might have an antiinflammatory effect. This review assesses the current state of knowledge regarding the immunomodulatory effect of moderate alcohol consumption.

摘要

动脉粥样硬化是西方国家的主要死因,是一种多因素疾病,局部低度炎症反应在其中起重要作用。炎症标志物升高可前瞻性地确定动脉粥样硬化并发症的风险并预测全因死亡率。饮酒与全因死亡率和心血管风险呈J形关系,这表明饮酒可能具有抗炎作用。本综述评估了关于适度饮酒的免疫调节作用的当前知识状况。

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