Division of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.
Pancreas. 2011 Aug;40(6):974-8. doi: 10.1097/MPA.0b013e3182156e1b.
In western countries, 7% to 10% of patients with pancreatic cancer (PC) have a familial predisposition to their disease. The aim of this study was to determine the familial susceptibility to PC in Japan.
Five hundred seventy-seven patients with PC and 577 age- and gender-matched controls were analyzed for cancer history in their first-degree relative(s) (FDRs) and demographic factors.
The patients with PC were more likely to have an FDR with PC (6.9%) than the controls (2.9%; odds ratio [OR], 2.5; P = 0.02). Three patients (0.5%), but none of the controls, had a family history of PC in multiple FDRs. Smoking, especially current smoking (OR, 1.5; P = 0.005), and diabetes mellitus (OR: 1.7, P = 0.001) were also associated with PC. The odds increased up to 10-fold if the patients were positive for these 3 factors. The patients with familial PC were more likely to be current smokers (40%) and to have diabetes mellitus (32.5%) than the sporadic cases (30.1% and 20.1%; OR, 1.6 and 1.9).
A family history of PC is a risk of PC in Japan (6.9%) as is a personal history of diabetes and smoking. It is prudent to inform the kindred of patients with familiar PC of the risk of smoking and to follow carefully if they develop diabetes.
在西方国家，7%至 10%的胰腺癌（PC）患者存在疾病的家族易感性。本研究旨在确定日本 PC 的家族易感性。
分析了 577 例 PC 患者和 577 名年龄和性别匹配的对照者，以确定其一级亲属（FDR）的癌症史和人口统计学因素。
PC 患者的 FDR 中有 PC 病史的比例（6.9%）高于对照组（2.9%；优势比[OR]，2.5；P = 0.02）。3 例患者（0.5%），但对照组中没有一例，存在多个 FDR 的 PC 家族史。吸烟，尤其是当前吸烟（OR，1.5；P = 0.005）和糖尿病（OR：1.7，P = 0.001）也与 PC 相关。如果患者存在这 3 个因素，则患病风险增加至 10 倍。有家族性 PC 的患者更可能是当前吸烟者（40%）和患有糖尿病（32.5%），而散发性病例的这两个比例分别为 30.1%和 20.1%（OR，1.6 和 1.9）。
日本存在 PC 的家族史（6.9%）、个人糖尿病史和吸烟史均为 PC 的风险因素。有家族性 PC 的患者的亲属应被告知吸烟的风险，并在其发生糖尿病时进行密切随访。
