Csp3-csp3 homocoupling reaction of benzyl halides catalyzed by rhodium.

作者信息

Sato Kazuyuki, Inoue Yuichi, Mori Tomohisa, Sakaue Atsushi, Tarui Atsushi, Omote Masaaki, Kumadaki Itsumaro, Ando Akira

机构信息

Faculty of Pharmaceutical Sciences, Setsunan University , 45-1, Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan.

出版信息

Org Lett. 2014 Jul 18;16(14):3756-9. doi: 10.1021/ol501619w. Epub 2014 Jun 30.

A highly reactive alkylrhodium complex was formed from Me(2)Zn and RhCl(PPh(3))(3) and effectively catalyzed a Csp(3)-Csp(3) homocoupling reaction of benzyl halides. A Csp(3)-Csp(3) coupling reaction using Rh catalyst has not been reported up to now. The reaction proceeded under very mild conditions and gave the corresponding homocoupling products even if they had reactive substituents such as an uncovered formyl or hydroxymethyl group.