Am J Psychiatry. 2014 Jul;171(7):723-8. doi: 10.1176/appi.ajp.2013.13050680.
Attention deficit hyperactivity disorder (ADHD) has been increasingly recognized and treated in children and adults in recent years. As a result, a growing number of women enter their reproductive years treated with medication for ADHD or are diagnosed and start medication during their reproductive years. A common question in perinatal psychiatry regards the risk-benefit profile of pharmacotherapy for ADHD, particularly with stimulants. At this time, there are no guidelines to inform the treatment of ADHD across pregnancy and the postpartum period. Concerns about in utero exposure to stimulants are based primarily on the impact these medications might have on fetal growth. While stimulants do not appear to be associated with major congenital malformations, more human data regarding potential behavioral teratogenicity are needed in order to understand both the short- and long-term risks. Severity of illness, presence of comorbid disorders, and degree of impairment have an impact on treatment decisions. Crucial considerations include driving safety and ability to function in occupational roles. While most women can successfully avoid the use of stimulant medication during pregnancy, there are cases in which the benefits of stimulant treatment outweigh known and putative risks of in utero medication exposure.
近年来,注意缺陷多动障碍(ADHD)在儿童和成人中越来越受到重视和治疗。因此,越来越多的女性在生育年龄接受 ADHD 药物治疗,或在生育年龄被诊断并开始药物治疗。围产期精神病学中的一个常见问题是 ADHD 药物治疗的风险-效益情况,特别是兴奋剂。目前,尚无指南可以指导整个怀孕期间和产后期间 ADHD 的治疗。对宫内暴露于兴奋剂的担忧主要基于这些药物可能对胎儿生长产生的影响。虽然兴奋剂似乎与主要先天畸形无关,但为了了解短期和长期风险,需要更多关于潜在行为致畸性的人类数据。疾病严重程度、合并症的存在以及损害程度都会对治疗决策产生影响。关键的考虑因素包括驾驶安全和在职业角色中发挥功能的能力。虽然大多数女性可以成功地在怀孕期间避免使用兴奋剂药物,但在某些情况下,兴奋剂治疗的益处超过了已知和推测的宫内药物暴露风险。