Department of Dermatology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan.
Br J Dermatol. 2014 Oct;171(4):779-85. doi: 10.1111/bjd.13234. Epub 2014 Sep 30.
The association between human papillomavirus (HPV) and squamous cell carcinoma (SCC) has been reported; however, the prevalence of HPV infection varies, and the clinical characteristics of HPV-positive cases remain unknown.
To elucidate the frequency of HPV infection in a series of Japanese patients with SCC and to identify the characteristics of HPV-positive cases.
We evaluated 38 patients with SCC treated at our department. HPV typing was performed using SCC samples from different body sites. Immunohistochemical staining for HPV proteins and p16(INK) (4a) was performed, in addition to polymerase chain reaction and in situ hybridization. The clinical characteristics of the HPV-positive cases were clarified.
Two genital lesions were positive for HPV type 16. Both cases showed basaloid features histopathologically, and were considered to have SCC that had arisen from bowenoid papulosis. p16(INK) (4a) expression was observed in 11 cases, including the two HPV-positive cases.
The present study indicates that the prevalence of HPV is not high and that bowenoid papulosis is an HPV-associated precancerous lesion. Further investigation is necessary to assess the relationship between HPV infection and SCC.
人乳头瘤病毒（HPV）与鳞状细胞癌（SCC）之间的关联已被报道；然而，HPV 感染的流行率存在差异，且 HPV 阳性病例的临床特征尚不清楚。
阐明一系列日本 SCC 患者中 HPV 感染的频率，并确定 HPV 阳性病例的特征。
我们评估了在我院接受治疗的 38 例 SCC 患者。对来自不同身体部位的 SCC 样本进行 HPV 分型。除聚合酶链反应和原位杂交外，还进行了 HPV 蛋白和 p16(INK)（4a）的免疫组织化学染色。阐明了 HPV 阳性病例的临床特征。
两个生殖器病变的 HPV 类型 16 呈阳性。两种情况在组织病理学上均表现为基底细胞样特征，被认为是来自鲍温样丘疹病的 SCC。包括两个 HPV 阳性病例在内的 11 例病例 p16(INK)（4a）表达阳性。
本研究表明 HPV 的流行率不高，鲍温样丘疹病是 HPV 相关的癌前病变。需要进一步研究来评估 HPV 感染与 SCC 之间的关系。
