Chai Liang, Ying Hong-Fang, Wu Ting-Ting, Zhou Shui-Hong, Bao Yang-Yang, Yao Hong-Tian, You Qi-Han
Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou City, Zhejiang Province 310003, China.
World J Surg Oncol. 2014 Jul 1;12:199. doi: 10.1186/1477-7819-12-199.
Small-cell neuroendocrine carcinoma (SCNEC) of the head and neck is rare. The prognosis of SCNEC in the nasal cavity and larynx is poor. The aim of this study was to investigate the clinicopathological features of nasal and laryngeal SCNEC and to determine the expression of HIF-1α, GLUT-1, PI3K, and p-Akt in SCNEC.
Between 2003 and 2012, 10 consecutive patients with histologically demonstrated nasal and laryngeal SCNEC were enrolled. Clinicopathological materials and follow-up data were analyzed retrospectively. Immunohistochemistry was used to detect GLUT-1, HIF-1α, PI3K, and p-Akt expression in paraffin wax-embedded tumor specimens.
The subjects were eight males and two females with a mean age of 60.8 (range: 53 to 71) years. Tumors were located in the maxillary sinus (n = 3) and larynx (n = 7). At last follow-up, four patients (40.0%) had local recurrence and five patients (50.0%) had developed distant metastases. Six patients died. The mean overall survival was 19.3 ± 2.1 months. Expression of GLUT-1, HIF-1α, PI3K, and p-Akt was seen in sinonasal and laryngeal SCNEC in 80 (8 out of 10), 50 (5 out of 10), 40 (4 out of 10), and 40% (4 out of 10) of cases, respectively. Expression of GLUT-1, HIF-1α, PI3K, and p-Akt was higher in sinonasal and laryngeal SCNEC than in precancerous lesions.
Primary sinonasal and laryngeal SCNEC is rare. This paper presents 10 cases of sinonasal and laryngeal SCNEC with more common local recurrence and distant metastasis. HIF-1α, GLUT-1, PI3K, and p-Akt expression was higher in sinonasal and laryngeal SCNEC than in precancerous lesions.
头颈部小细胞神经内分泌癌（SCNEC）较为罕见。鼻腔和喉SCNEC的预后较差。本研究的目的是调查鼻腔和喉SCNEC的临床病理特征，并确定SCNEC中HIF-1α、GLUT-1、PI3K和p-Akt的表达情况。
2003年至2012年期间，连续纳入10例经组织学证实的鼻腔和喉SCNEC患者。对临床病理资料和随访数据进行回顾性分析。采用免疫组织化学方法检测石蜡包埋肿瘤标本中GLUT-1、HIF-1α、PI3K和p-Akt的表达。
研究对象为8例男性和2例女性，平均年龄60.8岁（范围：53至71岁）。肿瘤位于上颌窦（n = 3）和喉（n = 7）。在最后一次随访时，4例患者（40.0%）出现局部复发，5例患者（50.0%）发生远处转移。6例患者死亡。平均总生存期为19.3±2.1个月。GLUT-1、HIF-1α、PI3K和p-Akt在鼻腔和喉SCNEC中的表达分别见于80%（10例中的8例）、50%（10例中的5例）、40%（10例中的4例）和40%（10例中的4例）的病例。鼻腔和喉SCNEC中GLUT-1、HIF-1α、PI3K和p-Akt的表达高于癌前病变。
原发性鼻腔和喉SCNEC较为罕见。本文报告了10例鼻腔和喉SCNEC，其局部复发和远处转移较为常见。鼻腔和喉SCNEC中HIF-1α、GLUT-1、PI3K和p-Akt的表达高于癌前病变。
