Rondla Naveen R, Ogilvie Jodi M, Pan Zhongda, Douglas Christopher J
Department of Chemistry, University of Minnesota, 207 Pleasant Street, SE, Minneapolis, Minnesota 55455, USA.
Chem Commun (Camb). 2014 Aug 18;50(64):8974-7. doi: 10.1039/c4cc04068f.
Reported here is a palladium catalyzed intramolecular acylcyanation of alkenes using α-iminonitriles. Through this method, highly functionalized indanones are synthesized in moderate to high yields using Pd(PPh3)4, without need for any additional ligands, and a common Lewis acid (ZnCl2). Additionally, the reaction tolerates substitution at various positions on the aromatic ring including electron donating and electron withdrawing groups.
本文报道了一种使用α-亚氨基腈的钯催化烯烃分子内酰基氰化反应。通过这种方法，使用Pd(PPh3)4，无需任何额外的配体和常见的路易斯酸（ZnCl2），以中等到高的产率合成了高度官能化的茚满酮。此外，该反应能够容忍芳环上不同位置的取代，包括供电子基团和吸电子基团。
